The University of Colorado Reproductive Medicine Unit (UC-RMU) is uniquely positioned to be an active and valuable participant in the Cooperative Multi-Center Reproductive Medicine Network of the NICHD. This proposal is jointly submitted by the Sections of Reproductive Endocrinology (Dept. of Obstetrics &Gynecology) and Urology (Department of Surgery). The strengths of this application include: 1) a 16 year history of close and integrated collaboration between the Principal Investigator (reproductive endocrinologist) and Co-Investigator (infertility urologist) in the diagnosis and treatment of infertility patients, 2) specially designed and physically contiguous clinical offices including shared reproductive laboratories, 3) outstanding experience in protocol development, and an extensive and highly successful record as effective contributors to many large multicenter trials including the NICHD Clinical Contraceptive Trials Network since 1996 and the existing Reproductive Medicine Network (RMN) since 2000, 4) a record of excellent patient outcomes and broad referral support from both University and community practitioners, and 5) significant departmental and institutional strengths, the support of numerous complementary clinical services and associated basic scientists, and outstanding resources. The geographic and population diversity represented by our location as one of the very few academic reproductive medicine centers in the Rocky Mountain region is an additional important asset that the UC-RMU brings to the RMN. Our application describes these strengths in detail, and illustrates the close and productive working relationship of reproductive endocrinology and urology with our Concept Protocol entitled """"""""A Prospective, Randomized, Placebo-Controlled, Double-Blind Study of Clomiphene Citrate Treatment of Infertile Men with Non-Obstructive Azoospermia"""""""". The goal of the RMN is to design and conduct clinical studies investigating problems in reproductive medicine, particularly those that impact fertility, and to facilitate resolution of these problems through a scientifically rigorous network of clinical research units. Individuals with reproductive diseases, infertile couples, and their health care providers will profit by this research. The public health will be enhanced by the birth of healthy, wanted babies, and by better understanding and treatment of conditions in both men and women that produce significant morbidity beyond their effects on fertility.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10HD038998-10S1
Application #
8468269
Study Section
Special Emphasis Panel (ZHD1-DSR-A (08))
Program Officer
De Paolo, Louis V
Project Start
2000-06-30
Project End
2013-07-31
Budget Start
2011-08-01
Budget End
2013-07-31
Support Year
10
Fiscal Year
2012
Total Cost
$159,291
Indirect Cost
$39,782
Name
University of Colorado Denver
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Diamond, Michael P; Legro, Richard S; Coutifaris, Christos et al. (2017) Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility. Am J Obstet Gynecol 217:191.e1-191.e19
Styer, Aaron K; Jin, Susan; Liu, Dan et al. (2017) Association of uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination for unexplained infertility. Fertil Steril 107:756-762.e3
Engmann, Lawrence; Jin, Susan; Sun, Fangbai et al. (2017) Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype. Am J Obstet Gynecol 216:493.e1-493.e13
Legro, Richard S; Dodson, William C; Kunselman, Allen R et al. (2016) Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS. J Clin Endocrinol Metab 101:2658-66
Mumford, Sunni L; Legro, Richard S; Diamond, Michael P et al. (2016) Baseline AMH Level Associated With Ovulation Following Ovulation Induction in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab 101:3288-96
Pal, Lubna; Zhang, Heping; Williams, Joanne et al. (2016) Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial. J Clin Endocrinol Metab 101:3027-35
Hansen, Karl R; He, Amy Linnea W; Styer, Aaron K et al. (2016) Predictors of pregnancy and live-birth in couples with unexplained infertility after ovarian stimulation-intrauterine insemination. Fertil Steril 105:1575-1583.e2
Hayes, M Geoffrey; Urbanek, Margrit; Ehrmann, David A et al. (2015) Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun 6:7502
Diamond, Michael P; Legro, Richard S; Coutifaris, Christos et al. (2015) Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. N Engl J Med 373:1230-40
Usadi, Rebecca S; Diamond, Michael P; Legro, Richard S et al. (2015) Recruitment strategies in two reproductive medicine network infertility trials. Contemp Clin Trials 45:196-200

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