The Maternal Fetal Medicine Network is one of the premiere groups of clinical investigators in the country. The Columbia Center has been privileged to be a member of this research collaborative for over 10 years and is now submitting a competitive renewal application for the next 5 years. The Columbia Perinatal Research Consortium (CPRC) is composed of 4 large perinatal centers working together under a single administrative structure administered by Columbia University. The centers have a long and successful history of collaborative multicentered research. During the last 5 year period of the MFMU, the CPRC has ranked first in both recruitment and data quality. CPRC faculty have designed and led major trials, performed ancillary studies and secondary analysis, served on subcommittees, and successfully presented concepts. The CPRC provides over 21,000 deliveries per year of which over 30% are high risk;has 29 MFM physicians, several of which have the protected time and expertise to be involved in Network activities;tertiary level NlCUs with neonatologists experienced in Network studies;well established infant follow-up programs;and over 35 nurses, recruiters and staff dedicated to network activities. Within this application is a concept evaluating the potential of statins (pravastatin) to treat and/or prevent preeclampsia in very high risk pregnancies. This concept is innovative and demonstrates the understanding that our center has of the value of a large collaborative network in evaluating important emerging technologies that require large population of patients.
Reducing perinatal and infant morbidity and mortality is important in improving the long term health of our country. By performing large prospective trials and studies of cutting edge technologies, the MFMU Network has been a leader in better understanding the underlying causes of these morbidities and in designing and testing treatments to reduce them.
|Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A; Blackwell, Sean C et al. (2016) Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. N Engl J Med 374:1311-20|
|Caritis, Steve N; Feghali, Maisa N; Grobman, William A et al. (2016) What we have learned about the role of 17-alpha-hydroxyprogesterone caproate in the prevention of preterm birth. Semin Perinatol 40:273-80|
|Yee, Lynn M; Sandoval, Grecio; Bailit, Jennifer et al. (2016) Maternal and Neonatal Outcomes With Early Compared With Delayed Pushing Among Nulliparous Women. Obstet Gynecol 128:1039-1047|
|Landon, Mark B; Grobman, William A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternalâ€“Fetal Medicine Units Network (2016) What We Have Learned About Trial of Labor After Cesarean Delivery from the Maternal-Fetal Medicine Units Cesarean Registry. Semin Perinatol 40:281-6|
|Froehlich, Rosemary J; Sandoval, Grecio; Bailit, Jennifer L et al. (2016) Association of Recorded Estimated Fetal Weight and Cesarean Delivery in Attempted Vaginal Delivery at Term. Obstet Gynecol 128:487-94|
|Manuck, Tracy A; Rice, Madeline Murguia; Bailit, Jennifer L et al. (2016) Preterm neonatal morbidity and mortality by gestational age: aÂ contemporary cohort. Am J Obstet Gynecol 215:103.e1-103.e14|
|Bloom, Steven L; Belfort, Michael; Saade, George et al. (2016) What we have learned about intrapartum fetal monitoring trials in the MFMU Network. Semin Perinatol 40:307-17|
|Salazar, Ashley; Tolivaisa, Susan; Allard, Donna et al. (2016) What we have learned about best practices for recruitment and retention in multicenter pregnancy studies. Semin Perinatol 40:321-7|
|Rice, Madeline Murguia; Landon, Mark B; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternalâ€“Fetal Medicine Units (MFMU) Network (2016) What we have learned about treating mild gestational diabetes mellitus. Semin Perinatol 40:298-302|
|Blackwell, Sean C; Landon, Mark B; Mele, Lisa et al. (2016) Relationship Between Excessive Gestational Weight Gain and Neonatal Adiposity in Women With Mild Gestational Diabetes Mellitus. Obstet Gynecol 128:1325-1332|
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