The Maternal Fetal Medicine Network is one of the premiere groups of clinical investigators in the country. The Columbia Center has been privileged to be a member of this research collaborative for over 10 years and is now submitting a competitive renewal application for the next 5 years. The Columbia Perinatal Research Consortium (CPRC) is composed of 4 large perinatal centers working together under a single administrative structure administered by Columbia University. The centers have a long and successful history of collaborative multicentered research. During the last 5 year period of the MFMU, the CPRC has ranked first in both recruitment and data quality. CPRC faculty have designed and led major trials, performed ancillary studies and secondary analysis, served on subcommittees, and successfully presented concepts. The CPRC provides over 21,000 deliveries per year of which over 30% are high risk;has 29 MFM physicians, several of which have the protected time and expertise to be involved in Network activities;tertiary level NlCUs with neonatologists experienced in Network studies;well established infant follow-up programs;and over 35 nurses, recruiters and staff dedicated to network activities. Within this application is a concept evaluating the potential of statins (pravastatin) to treat and/or prevent preeclampsia in very high risk pregnancies. This concept is innovative and demonstrates the understanding that our center has of the value of a large collaborative network in evaluating important emerging technologies that require large population of patients.

Public Health Relevance

Reducing perinatal and infant morbidity and mortality is important in improving the long term health of our country. By performing large prospective trials and studies of cutting edge technologies, the MFMU Network has been a leader in better understanding the underlying causes of these morbidities and in designing and testing treatments to reduce them.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD040485-15
Application #
8638042
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Ilekis, John V
Project Start
2001-04-01
Project End
2016-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10032
Varner, Michael W; Rice, Madeline Murguia; Landon, Mark B et al. (2017) Pregnancies After the Diagnosis of Mild Gestational Diabetes Mellitus and Risk of Cardiometabolic Disorders. Obstet Gynecol 129:273-280
Tita, Alan T N; Lai, Yinglei; Landon, Mark B et al. (2017) Predictive Characteristics of Elevated 1-Hour Glucose Challenge Test Results for Gestational Diabetes. Am J Perinatol 34:1464-1469
Chauhan, Suneet P; Rice, Madeline Murguia; Grobman, William A et al. (2017) Neonatal Morbidity of Small- and Large-for-Gestational-Age Neonates Born at Term in Uncomplicated Pregnancies. Obstet Gynecol 130:511-519
Casey, Brian M; Thom, Elizabeth A; Peaceman, Alan M et al. (2017) Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy. N Engl J Med 376:815-825
Yee, Lynn M; Costantine, Maged M; Rice, Madeline Murguia et al. (2017) Racial and Ethnic Differences in Utilization of Labor Management Strategies Intended to Reduce Cesarean Delivery Rates. Obstet Gynecol 130:1285-1294
Silver, Robert M; Myatt, Leslie; Hauth, John C et al. (2017) Cell-Free Total and Fetal DNA in First Trimester Maternal Serum and Subsequent Development of Preeclampsia. Am J Perinatol 34:191-198
McDonnold, Mollie; Mele, Lisa M; Myatt, Leslie et al. (2016) Waist-to-Hip Ratio versus Body Mass Index as Predictor of Obesity-Related Pregnancy Outcomes. Am J Perinatol 33:618-24
Basraon, Sanmaan K; Mele, Lisa; Myatt, Leslie et al. (2016) Relationship of Early Pregnancy Waist-to-Hip Ratio versus Body Mass Index with Gestational Diabetes Mellitus and Insulin Resistance. Am J Perinatol 33:114-21
Blackwell, Sean C; Landon, Mark B; Mele, Lisa et al. (2016) Relationship Between Excessive Gestational Weight Gain and Neonatal Adiposity in Women With Mild Gestational Diabetes Mellitus. Obstet Gynecol 128:1325-1332
Hughes, Brenna L; Clifton, Rebecca G; Hauth, John C et al. (2016) Is Mid-trimester Insulin Resistance Predictive of Subsequent Puerperal Infection? A Secondary Analysis of Randomized Trial Data. Am J Perinatol 33:983-90

Showing the most recent 10 out of 157 publications