Contained in this submission is the CPCCRN Los Angeles Center's reapplication for continued membership in the Collaborative Pediatric Critical Care Research Network. The center is a partnership between the two major universities within the Los Angeles area, the Children's Hospital of Los Angeles (USC) and Mattel Children's Hospital UCLA (UCLA). Both sites have been members of the CPCCRN for the last five years and have been participating in conducting clinical studies under the CPCCRN. The partnership has continued to be strong between the two sites and it is the intention of both to participate in the network as a combined site. Concept Application Summary The purpose of this study is to compare two different early lung protective ventilation strategies (high frequency oscillatory ventilation versus pressure controlled conventional ventilation) for children with acute lung injury. In order to overcome limitations highlighted in previous trials on pediatric Acute Lung Injury, non-invasive markers of lung injury will be used to both improve patient enrollment and characterize risk. Application of already developed computer-based decision support tools will ensure replicable clinical decisions for equivalent patient states and improve protocol adherence. Neurodevelopmental and pulmonary outcome measures from Acute Lung Injury will be evaluated to examine morbidity and mortality beyond the PICU discharge.

Public Health Relevance

Site Application Relevance: Continued membership of CHLA-UCLA in the network provides a broader range of expertise and larger multi-ethnic patient population by having two major universities contributing to its goals. Concept Relevance: The study seeks to evaluate the effects of early high frequency oscillatory ventilation compared to lung protective pressure control ventilation on short and long term morbidity and mortality.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD050012-07
Application #
8010140
Study Section
Special Emphasis Panel (ZHD1-DSR-A (25))
Program Officer
Nicholson, Carol E
Project Start
2005-05-01
Project End
2014-11-30
Budget Start
2010-12-01
Budget End
2011-11-30
Support Year
7
Fiscal Year
2011
Total Cost
$291,798
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
052277936
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
Moler, Frank W; Silverstein, Faye S; Holubkov, Richard et al. (2017) Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med 376:318-329
Cashen, Katherine; Reeder, Ron; Dalton, Heidi J et al. (2017) Functional Status of Neonatal and Pediatric Patients After Extracorporeal Membrane Oxygenation. Pediatr Crit Care Med 18:561-570
Slomine, Beth S; Nadkarni, Vinay M; Christensen, James R et al. (2017) Pediatric cardiac arrest due to drowning and other respiratory etiologies: Neurobehavioral outcomes in initially comatose children. Resuscitation 115:178-184
Newth, Christopher J L; Sward, Katherine A; Khemani, Robinder G et al. (2017) Variability in Usual Care Mechanical Ventilation for Pediatric Acute Respiratory Distress Syndrome: Time for a Decision Support Protocol? Pediatr Crit Care Med 18:e521-e529
Carcillo, Joseph A; Sward, Katherine; Halstead, E Scott et al. (2017) A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis. Pediatr Crit Care Med 18:143-150
Carcillo, Joseph A; Halstead, E Scott; Hall, Mark W et al. (2017) Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome. Pediatr Crit Care Med 18:513-523
Berger, John T; Holubkov, Richard; Reeder, Ron et al. (2017) Morbidity and mortality prediction in pediatric heart surgery: Physiological profiles and surgical complexity. J Thorac Cardiovasc Surg 154:620-628.e6
Moler, Frank W; Hutchison, Jamie S; Nadkarni, Vinay M et al. (2016) Targeted Temperature Management After Pediatric Cardiac Arrest Due To Drowning: Outcomes and Complications. Pediatr Crit Care Med 17:712-20
Keele, Linda; Meert, Kathleen L; Berg, Robert A et al. (2016) Limiting and Withdrawing Life Support in the PICU: For Whom Are These Options Discussed? Pediatr Crit Care Med 17:110-20
Zimmerman, Jerry J; Anand, Kanwaljeet J S; Meert, Kathleen L et al. (2016) Research as a Standard of Care in the PICU. Pediatr Crit Care Med 17:e13-21

Showing the most recent 10 out of 63 publications