The University of New Mexico proposes to continue to help the NICHD Neonatal Research Network achieve its primary objective of advancing the field of Neonatal-Perinatal Medicine through a network of academic centers performing rigorous, multi-center clinical protocols to investigate the safety and efficacy of treatment and management strategies for newborn infants. UNM has shown its commitment to all facets of the Network mission. The PI, Kristi Watterberg, and Alternate PI, Robin Ohls, have extensive experience in designing and implementing clinical studies, both independently and within the Network. Dr. Watterberg is PI for a planned RCT of hydrocortisone to treat BPD (approved by the NRN advisory board), serves on the Protocol Review Subcommittee which provides critical peer review for Network studies, is Vice-Chair of two protocol subcommittees, and has brought additional investigators and protocols to the Network. Dr. Ohls serves on protocol subcommittees, participates in protocol development, and continues her independent research, including a multicenter RCT of erythropoiesis-stimulating agents (PI) with NIH-funded neurodevelopmental outcomes assessments. Additional UNM investigators include Erika Fernandez (Supplemental Award) who developed a protocol, "Hydrocortisone Treatment of Hypotension in Term and Late Preterm Infants," has completed the first, observational, phase and is planning the second phase, an RCT. Andrea Duncan and Jean Lowe are conducting an ancillary study to assess the correlation of working memory at 18-22 months with executive function at school age. Additional strengths include large under-represented Hispanic and Native American populations (53% and 22% of UNM enrollment in the generic database (GDB));a statewide outreach and transport system resulting in >85% of VLBW infants being inborn;a General Clinical Research Center Pediatric Scatterbed Program (directed by Dr. Ohls) now transitioning to a Clinical and Translational Science Center;and a comprehensive Developmental Care program, resulting in a GDB follow-up rate of 92%. The facilities, programs and patient populations at UNM, together with the expertise and experience of its investigators, make UNM a worthy continuing contributor to the Neonatal Research Network.
Advancement of evidence-based best health care practices requires the performance of large, well-done clinical trials. Newborn Intensive Care Units do not have enough patients to accomplish this individually;therefore, NIH developed a Neonatal Research Network of academic centers to advance health care for sick infants by performing rigorous multi-center clinical studies. The University of New Mexico has been a highly productive Network contributor and proposes to continue its participation during the next funding cycle.
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|Wadhawan, R; Oh, W; Hintz, S R et al. (2014) Neurodevelopmental outcomes of extremely low birth weight infants with spontaneous intestinal perforation or surgical necrotizing enterocolitis. J Perinatol 34:64-70|
|Davis, A S; Hintz, S R; Goldstein, R F et al. (2014) Outcomes of extremely preterm infants following severe intracranial hemorrhage. J Perinatol 34:203-8|
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|Stevens, Timothy P; Finer, Neil N; Carlo, Waldemar A et al. (2014) Respiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT). J Pediatr 165:240-249.e4|
|Pappas, Athina; Kendrick, Douglas E; Shankaran, Seetha et al. (2014) Chorioamnionitis and early childhood outcomes among extremely low-gestational-age neonates. JAMA Pediatr 168:137-47|
|Kelleher, John; Salas, Ariel A; Bhat, Ramachandra et al. (2014) Prophylactic indomethacin and intestinal perforation in extremely low birth weight infants. Pediatrics 134:e1369-77|
|Morriss Jr, Frank H; Saha, Shampa; Bell, Edward F et al. (2014) Surgery and neurodevelopmental outcome of very low-birth-weight infants. JAMA Pediatr 168:746-54|
|Boghossian, Nansi S; Hansen, Nellie I; Bell, Edward F et al. (2014) Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18. Pediatrics 133:226-35|
|Randolph, David A; Nolen, Tracy L; Ambalavanan, Namasivayam et al. (2014) Outcomes of extremely low birthweight infants with acidosis at birth. Arch Dis Child Fetal Neonatal Ed 99:F263-8|
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