This is the application of the Division of Neonatology at the University of Utah to continue in the Cooperative Multicenter Neonatal Research Network (NRN). The NRN objective is to conduct rigorous clinical research in the care of high-risk (particularly low birth weight) newborn infants, by providing sufficient diverse patient availability to answer important clinical questions in a timely, powerful and generalizable manner. Our NICUs remain well positioned to further these objectives. Specific strengths that the Division offers include: 1. Productive contributions to the Network during the 2006 cycle. 2. More than 2,000 admissions to our NICUs and over 9,500 on-site deliveries annually, with demographic mix different from the rest of the NRN. 3. A collaborative and productive relationship with our Division of Maternal Fetal Medicine, an exemplary participant in the NICHD Maternal Fetal Medicine Network (MFMU) that shares data and resources with us. Our continued participation in the NRN will benefit both networks. 4. Numerous other available resources remain: a) Utah Population Database, a unique resource to investigate genetic bases of newborn pathologic phenotypes;b) University of Utah CCTA and associated core facilities;d) Pediatric Pharmacology Program;e) interaction with multiple other research networks now under the rubric of the new University Institute for Woman and Child, including (but not limited to) the Pediatric Heart Disease Clinical Research Network, Pediatric Emergency Care Applied Research Network, the National Children's Study (Salt Lake County is a Vanguard Location and the University Department of Pediatrics is a Vanguard Center), the MFMU, and the NRN. To show how these resources can be used to answer important questions in low birth weight infants, we propose a study testing the hypothesis that thyroxine treatment of VLBW infants >7 days old with transient hypothyroxinemia will result in improved survival without neurodevelopmental impairment at 18-22 months. In summary, this application presents our continued commitment to further the clinical research mission of the NICHD NRN.

Public Health Relevance

Improvement in survival and long-term outcome of high-risk newborn infants is essential to assure a healthy, productive population. Doing so in a cost-effective manner will further bolster the strength of our society. The NRN is targeted to fulfill these goals.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD053124-08
Application #
8456083
Study Section
Special Emphasis Panel (ZHD1-DSR-A (03))
Program Officer
Raju, Tonse N
Project Start
2006-04-01
Project End
2016-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
8
Fiscal Year
2013
Total Cost
$6,707
Indirect Cost
$2,210
Name
University of Utah
Department
Pediatrics
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Fernandez, Erika; Watterberg, Kristi L; Faix, Roger G et al. (2014) Incidence, management, and outcomes of cardiovascular insufficiency in critically ill term and late preterm newborn infants. Am J Perinatol 31:947-56
Davis, A S; Hintz, S R; Goldstein, R F et al. (2014) Outcomes of extremely preterm infants following severe intracranial hemorrhage. J Perinatol 34:203-8
Stevens, Timothy P; Finer, Neil N; Carlo, Waldemar A et al. (2014) Respiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT). J Pediatr 165:240-249.e4
Pappas, Athina; Kendrick, Douglas E; Shankaran, Seetha et al. (2014) Chorioamnionitis and early childhood outcomes among extremely low-gestational-age neonates. JAMA Pediatr 168:137-47
Kelleher, John; Salas, Ariel A; Bhat, Ramachandra et al. (2014) Prophylactic indomethacin and intestinal perforation in extremely low birth weight infants. Pediatrics 134:e1369-77
Morriss Jr, Frank H; Saha, Shampa; Bell, Edward F et al. (2014) Surgery and neurodevelopmental outcome of very low-birth-weight infants. JAMA Pediatr 168:746-54
Randolph, David A; Nolen, Tracy L; Ambalavanan, Namasivayam et al. (2014) Outcomes of extremely low birthweight infants with acidosis at birth. Arch Dis Child Fetal Neonatal Ed 99:F263-8
Wynn, James L; Hansen, Nellie I; Das, Abhik et al. (2013) Early sepsis does not increase the risk of late sepsis in very low birth weight neonates. J Pediatr 162:942-8.e1-3
Adams-Chapman, Ira; Hansen, Nellie I; Shankaran, Seetha et al. (2013) Ten-year review of major birth defects in VLBW infants. Pediatrics 132:49-61
Adams-Chapman, Ira; Bann, Carla M; Vaucher, Yvonne E et al. (2013) Association between feeding difficulties and language delay in preterm infants using Bayley Scales of Infant Development-Third Edition. J Pediatr 163:680-5.e1-3

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