In response to RFA-HD-14-018, we are re-competing for the Data Coordination Center (DCC) as a part of the Cooperative Multicenter Reproductive Medicine Network (RMN) and will be responsible for Study Design, Conduct, Analyses and Publications;Data Management;Site Monitoring;Regulatory Requirements;and Financial Administration as a continuation of our current work. We will participate in a highly cooperative manner and provide vital support to the Clinical Sites and the NICHD in all aspects of the RMN. For example, we will communicate regularly with and report in a timely manner to the NICHD Program Administrators, Steering Committee (SC), Data and Safety Monitoring Board (DSMB), Advisory Board (AB) and RMN investigators;actively participate in all aspects of protocol development;arrange logistics for RMN-related meetings and teleconferences;prepare and distribute meeting and teleconference agendas, minutes, and action items for the RMN committees and boards;conduct site monitoring visits;oversee biospecimen management;monitor adverse events;assist RMN with regulatory requirements;collaborate with study drug and biorepository representatives;provide or coordinate training for study personnel;facilitate data and resource sharing and retrieve the data generated from the RMN samples used by outside investigators;perform data quality control, analysis and reporting;manage the protocol-related costs;and most importantly, initiate and/or collaborate in scientific publications. The RMN has experienced unprecedented productivity, exceeding our goals in many areas. As a key contributor to this success, our DCC """"""""stands tall with the best of the best."""""""" The RMN has greatly enjoyed and benefited from our presence and contribution, and vice versa. We have full support from our institution, including world renowned facilities and information technology. We are determined to advance the RMN and NICHD mission for improving infertility treatment, and more broadly, public health policy and practice.

Public Health Relevance

The RMN has an important mission to enhance conception, live birth, and the health of children born to women and men with impaired fertility, and more broadly, to improve public health policy and practice. We at the DCC serve many of the RMN central functions in order to achieve the RMN aims, and hence play a significant role in advancing reproductive sciences and improving the clinical practice for infertility treatment.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Study Section
Special Emphasis Panel (ZHD1-DSR-L (50))
Program Officer
De Paolo, Louis V
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Yale University
Public Health & Prev Medicine
Schools of Medicine
New Haven
United States
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Kent, James; Dodson, William C; Kunselman, Allen et al. (2018) Gestational Weight Gain in Women With Polycystic Ovary Syndrome: A Controlled Study. J Clin Endocrinol Metab 103:4315-4323
Greenwood, Eleni A; Pasch, Lauri A; Cedars, Marcelle I et al. (2018) Insulin resistance is associated with depression risk in polycystic ovary syndrome. Fertil Steril 110:27-34
Barnhart, Kurt T; Sammel, Mary D; Stephenson, Mary et al. (2018) Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial. Contemp Clin Trials 73:145-151
Evans-Hoeker, Emily A; Eisenberg, Esther; Diamond, Michael P et al. (2018) Major depression, antidepressant use, and male and female fertility. Fertil Steril 109:879-887
Hansen, Karl R; Eisenberg, Esther; Baker, Valerie et al. (2018) Midluteal Progesterone: A Marker of Treatment Outcomes in Couples With Unexplained Infertility. J Clin Endocrinol Metab 103:2743-2751
Diamond, Michael P; Legro, Richard S; Coutifaris, Christos et al. (2017) Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility. Am J Obstet Gynecol 217:191.e1-191.e19
Engmann, Lawrence; Jin, Susan; Sun, Fangbai et al. (2017) Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype. Am J Obstet Gynecol 216:493.e1-493.e13
Greenwood, Eleni A; Cedars, Marcelle I; Santoro, Nanette et al. (2017) Antim├╝llerian hormone levels and antral follicle counts are not reduced compared with community controls in patients with rigorously defined unexplained infertility. Fertil Steril 108:1070-1077
Mumford, Sunni L; Legro, Richard S; Diamond, Michael P et al. (2016) Baseline AMH Level Associated With Ovulation Following Ovulation Induction in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab 101:3288-96
Pal, Lubna; Zhang, Heping; Williams, Joanne et al. (2016) Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial. J Clin Endocrinol Metab 101:3027-35

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