This proposal seeks to describe this organizational structure, provider engagement, study subject recruitment and retention strategies, protocol implementation procedures, and scientific capabilities of the Northwestern Study Center to meet the overall objectives of the investigation: """"""""Preterm birth in nulliparous women: an understudied population at great risk."""""""" The ultimate aims of this observational study of nulliparous women are: to identify maternal characteristics (i.e. environmental, genetic, physiologic) that are associated with preterm delivery;to identify placental characteristics (i.e. developmental and functional) that are associated with preterm delivery;to identify fetal characteristics (i.e. genetic, growth, developmental) that are associated with preterm delivery;and to use these characteristics to better predict preterm delivery and understand the mechanisms that underlie it. Correspondingly, the Northwestern Study Center will: 1. Provide an effective organizational structure and management approach to support the objectives of the """"""""Preterm birth in nulliparous women"""""""" study;2. Utilize and expand upon the existing relationships of the Northwestern Study Center to develop and implement effective strategies for the recruitment of nulliparous parturients and the retention of these subjects throughout the study;3. Establish and implement survey data, ultrasound examination, physical examination, and specimen collection processes that meet the requirements of the """"""""Preterm birth in nulliparous women"""""""" study;and 4. Contribute to the scientific collaboration among the clinical centers to support the study's objectives and make full and innovative use of the unique data resulting from the """"""""Preterm birth in nulliparous women"""""""" study.

Public Health Relevance

Nulliparous women account for a disproportionate share of adverse pregnancy outcomes, and in particular of preterm births, which are responsible for a signficant health and financial burden. The proposed research network and study has the potential to enhance our undertanding of the etiologies and prediction of preterm birth, and therein will help to guide the development of targeted prevention and therapeutic strategies.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD063020-03
Application #
8204591
Study Section
Special Emphasis Panel (ZHD1-DSR-K (29))
Program Officer
Higgins, Rosemary
Project Start
2010-01-10
Project End
2014-12-31
Budget Start
2012-01-01
Budget End
2013-12-31
Support Year
3
Fiscal Year
2012
Total Cost
$197,500
Indirect Cost
$67,992
Name
Northwestern University at Chicago
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Grobman, William A; Parker, Corette B; Willinger, Marian et al. (2018) Racial Disparities in Adverse Pregnancy Outcomes and Psychosocial Stress. Obstet Gynecol 131:328-335
Haas, David M; Marsh, Derek J; Dang, Danny T et al. (2018) Prescription and Other Medication Use in Pregnancy. Obstet Gynecol 131:789-798
Louis, Judette M; Koch, Matthew A; Reddy, Uma M et al. (2018) Predictors of sleep-disordered breathing in pregnancy. Am J Obstet Gynecol 218:521.e1-521.e12
Facco, Francesca L; Grobman, William A; Reid, Kathryn J et al. (2017) Objectively measured short sleep duration and later sleep midpoint in pregnancy are associated with a higher risk of gestational diabetes. Am J Obstet Gynecol 217:447.e1-447.e13
Reid, Kathryn J; Facco, Francesca L; Grobman, William A et al. (2017) Sleep During Pregnancy: The nuMoM2b Pregnancy and Sleep Duration and Continuity Study. Sleep 40:
Esplin, M Sean; Elovitz, Michal A; Iams, Jay D et al. (2017) Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women. JAMA 317:1047-1056
Parry, Samuel; Sciscione, Anthony; Haas, David M et al. (2017) Role of early second-trimester uterine artery Doppler screening to predict small-for-gestational-age babies in nulliparous women. Am J Obstet Gynecol 217:594.e1-594.e10
Facco, Francesca L; Parker, Corette B; Reddy, Uma M et al. (2017) Association Between Sleep-Disordered Breathing and Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus. Obstet Gynecol 129:31-41
Bodnar, Lisa M; Simhan, Hyagriv N; Parker, Corette B et al. (2017) Racial or Ethnic and Socioeconomic Inequalities in Adherence to National Dietary Guidance in a Large Cohort of US Pregnant Women. J Acad Nutr Diet 117:867-877.e3
Bann, Carla M; Parker, Corette B; Grobman, William A et al. (2017) Psychometric properties of stress and anxiety measures among nulliparous women. J Psychosom Obstet Gynaecol 38:53-62

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