Pediatric Critical Care Medicine Incorporates a multidisciplinary approach to address the medical needs of the most fragile population of critically III and Injured children. Fortunately, improvements in care over the past decades have impacted mortality for all PICU patients such that current annual rates at most academic, tertiary care centers are below 5%. However, certain disease processes notably acute lung injury and sepsis, remain associated with significantly higher mortality rates as well as consume substantial health care resources. Despite this, the occurrences of these most challenging diseases do not occur sufficiently often at any one center to enable an effective, single-site study that will advance both our understanding and management of these diseases. Mindful of this reality, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) showed great wisdom in funding an infrastructure to address the need to create a multi-center research network, the Collaborative Pediatric Critical Care Research Network (CPCCRN). Our rapidly evolving program at the University of Michigan has made great strides in establishing a local Infrastructure to allow us to actively participate in a number of network-base studies. In addition to possessing this infrastructure capacity, we also believe we have a team of investigators who can make important scientific and leadership contributions to this network. As a result, we are applying to become a participating site within CPCCRN to assistant in executing investigations of pathobiology, management strategies, and the safety and efficacy of treatments for critically ill or injured children. As part of this application, we have submitted a Concept Proposal which reflects both our Infrastructure and Intellectual capacity to contribute in a productive manner to CPCCRN. We hypothesize that an Improved understanding of the mechanisms regulating gene expression associated with host Immune dysfunction In the late phase of critical Illnesses will identify novel therapeutic targets for further improving outcomes.
This concept study is a reflection of our program's overall goal to contribute in a meaningful way to the on-going growth and success of a research network that is committed to improving both the short- and long-term outcomes of critically ill and injured children.
|Carcillo, Joseph A; Dean, J Michael; Holubkov, Richard et al. (2016) Inherent Risk Factors for Nosocomial Infection in the Long Stay Critically Ill Child Without Known Baseline Immunocompromise: A Post Hoc Analysis of the CRISIS Trial. Pediatr Infect Dis J 35:1182-1186|
|Carcillo, Joseph A; Sward, Katherine; Halstead, E Scott et al. (2016) A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis. Pediatr Crit Care Med :|
|Keele, Linda; Meert, Kathleen L; Berg, Robert A et al. (2016) Limiting and Withdrawing Life Support in the PICU: For Whom Are These Options Discussed? Pediatr Crit Care Med 17:110-20|
|Sward, Katherine A; Rubin, Sarah; Jenkins, Tammara L et al. (2016) Case Study: Semantic Annotation of a Pediatric Critical Care Research Study. Comput Inform Nurs 34:101-4|
|Berg, Robert A; Nadkarni, Vinay M; Clark, Amy E et al. (2016) Incidence and Outcomes of Cardiopulmonary Resuscitation in PICUs. Crit Care Med 44:798-808|
|Pollack, Murray M; Holubkov, Richard; Funai, Tomohiko et al. (2016) The Pediatric Risk of Mortality Score: Update 2015. Pediatr Crit Care Med 17:2-9|
|Meert, Kathleen L; Eggly, Susan; Kavanaugh, Karen et al. (2015) Meaning making during parent-physician bereavement meetings after a child's death. Health Psychol 34:453-61|
|Frey, Lewis J; Sward, Katherine A; Newth, Christopher J L et al. (2015) Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network. J Am Med Inform Assoc 22:1271-6|
|Pollack, Murray M; Holubkov, Richard; Funai, Tomohiko et al. (2015) Simultaneous Prediction of New Morbidity, Mortality, and Survival Without New Morbidity From Pediatric Intensive Care: A New Paradigm for Outcomes Assessment. Crit Care Med 43:1699-709|
|Dalton, Heidi J; Garcia-Filion, Pamela; Holubkov, Richard et al. (2015) Association of bleeding and thrombosis with outcome in extracorporeal life support. Pediatr Crit Care Med 16:167-74|
Showing the most recent 10 out of 19 publications