Critical care has excellent measures of severity of illness calibrated to mortality, but severity may be reflected in subsequent morbidity as well survival. A major challenge of critical care outcomes research and applicable to all medical outcomes and quality issues is the development of methods that predict the full range of outcomes from normal through the range of morbidities as well as death.
The AIM of this proposal is to develop and validate a predictor of 3 or more outcome states from pediatric intensive care: death, survival one or more states of reduced functional status, and survival with normal or unchanged functional status. Preliminary Studies demonstrate a) the feasibility of the statistical approach and b) the applicability and utility of a new functional status assessment method (Functional Status Score, FSS) developed by the CPCCRN and by this PI for the purpose of this proposal. METHODS: Consecutive patients without exclusion from the participating PICUS will be utilized. Core data will consist of physiological data, diagnoses, age and other demographic information, FSS (pre-admission, PICU discharge, hospital discharge), survival/death (PICU and hospital), therapies affecting functional status, imaging, Outcome prediction for multiple functional states with normal function and death being the extreme will include both """"""""simple"""""""" linear models with the FSS contributing the gradations of outcome, and polychotomous logistic regression analysis for models of 3 or more discrete outcome states. Statistical models will use up to 12 predictor variables including PRISM III score without neurological variables, neurological variables only, pre- ICU care area, operative status, diagnoses (up to 6), age, baseline FSS. Statistical methods will include """"""""simple"""""""" linear regression conceptualizing outcome on a scale of normal to death with worsening functional states in between and polychotomous logistic regression utilizing the FSS to define 2 of more outcome states in addition to death. Sample size estimates based on a 4% mortality rate and a 4% new severe functional status are 5067 but will be re-estimated when units are selected.

Public Health Relevance

Shifting the paradigm of severity assessment by advancing its conceptual and statistical foundations will stimulate change. Important advances could occur in quality research and methods, long-term outcome forecasting including pediatric disability at PICU discharge, and decision making by including severely decreased functional status probabilities as well as mortality probabilities based on admission severity.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-A (25))
Program Officer
Maholmes, Valerie
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Phoenix Children's Hospital
United States
Zip Code
Carcillo, Joseph A; Dean, J Michael; Holubkov, Richard et al. (2016) Inherent Risk Factors for Nosocomial Infection in the Long Stay Critically Ill Child Without Known Baseline Immunocompromise: A Post Hoc Analysis of the CRISIS Trial. Pediatr Infect Dis J 35:1182-1186
Keele, Linda; Meert, Kathleen L; Berg, Robert A et al. (2016) Limiting and Withdrawing Life Support in the PICU: For Whom Are These Options Discussed? Pediatr Crit Care Med 17:110-20
Sward, Katherine A; Rubin, Sarah; Jenkins, Tammara L et al. (2016) Case Study: Semantic Annotation of a Pediatric Critical Care Research Study. Comput Inform Nurs 34:101-4
Pollack, Murray M (2016) Severity of Illness Confusion. Pediatr Crit Care Med 17:583
Berg, Robert A; Nadkarni, Vinay M; Clark, Amy E et al. (2016) Incidence and Outcomes of Cardiopulmonary Resuscitation in PICUs. Crit Care Med 44:798-808
Pollack, Murray M; Holubkov, Richard; Funai, Tomohiko et al. (2016) The Pediatric Risk of Mortality Score: Update 2015. Pediatr Crit Care Med 17:2-9
Meert, Kathleen L; Eggly, Susan; Kavanaugh, Karen et al. (2015) Meaning making during parent-physician bereavement meetings after a child's death. Health Psychol 34:453-61
Frey, Lewis J; Sward, Katherine A; Newth, Christopher J L et al. (2015) Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network. J Am Med Inform Assoc 22:1271-6
Pollack, Murray M; Holubkov, Richard; Funai, Tomohiko et al. (2015) Simultaneous Prediction of New Morbidity, Mortality, and Survival Without New Morbidity From Pediatric Intensive Care: A New Paradigm for Outcomes Assessment. Crit Care Med 43:1699-709
Dalton, Heidi J; Garcia-Filion, Pamela; Holubkov, Richard et al. (2015) Association of bleeding and thrombosis with outcome in extracorporeal life support. Pediatr Crit Care Med 16:167-74

Showing the most recent 10 out of 22 publications