The University of New Mexico (UNM) proposes to join the Pelvic Floor Disorders Network (PFDN) to achieve the Network's primary goal of conducting rigorous, multi-center clinical trials to investigate the clinical and health aspects of pelvic floor disorders in women. Our site, in collaboration with other Network sites, aims to reduce the burden of pelvic floor disorders on women and their families. Through the design of innovative trials and participation in ongoing studies, the UNM PFDN site will make significant contributions to the Network. Dr. Rogers, Principal Investigator, and Dr. Komesu, Alternate Principal Investigator, have extensive experience in the design and conduct of multi-center randomized trials and proven leadership and productivity. The UNM PFDN site brings to the Network a busy clinical service with large numbers of under- represented Hispanic and Native American populations, as well as broad institutional support from the Department of Obstetrics and Gynecology and a recently funded Clinical and Translational Research Center. The concept proposal, based on preliminary data generated by our site and the work of others, is an innovative investigation comparing hypnotherapy to long-acting anticholinergic medicine for the treatment of overactive bladder (OAB). In addition to the hypnotherapy comparative-effectiveness trial, the concept proposal focuses investigation into the underlying mechanisms of OAB on the brain, using functional magnetic resonance imaging (fMRI). This translational, comparative effectiveness clinical trial is an excellent example of cutting edge research that the UNM PFDN site will bring to the Network. Skilled investigators, a busy clinical practice, unique patient populations and broad institutional support make UNM a worthy new clinical site for the PFDN.

Public Health Relevance

Pelvic floor disorders are common and costly. Performance of rigorously designed, target randomized clinical trials that inform evidence-base health care practices for women with pelvic floor disorders is best done through collaboration with other clinical sites. The University of New Mexico is a highly productive clinical and research site and proposes to join the Pelvic Floor Disorders Network in order to meet the Network's goal of investigating innovative solutions to these common problems.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZHD1-DSR-N (02))
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Parrott, Estella C
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University of New Mexico Health Sciences Center
Obstetrics & Gynecology
Schools of Medicine
United States
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Nager, Charles W; Zyczynski, Halina; Rogers, Rebecca G et al. (2016) The Design of a Randomized Trial of Vaginal Surgery for Uterovaginal Prolapse: Vaginal Hysterectomy With Native Tissue Vault Suspension Versus Mesh Hysteropexy Suspension (The Study of Uterine Prolapse Procedures Randomized Trial). Female Pelvic Med Reconstr Surg 22:182-9
Sung, Vivian W; Borello-France, Diane; Dunivan, Gena et al. (2016) Methods for a multicenter randomized trial for mixed urinary incontinence: rationale and patient-centeredness of the ESTEEM trial. Int Urogynecol J 27:1479-90
Amundsen, Cindy L; Richter, Holly E; Menefee, Shawn A et al. (2016) OnabotulinumtoxinA vs Sacral Neuromodulation on Refractory Urgency Urinary Incontinence in Women: A Randomized Clinical Trial. JAMA 316:1366-1374
Cichowski, Sara B; Dunivan, Gena C; Rogers, Rebecca G et al. (2015) Standard compared with mnemonic counseling for fecal incontinence: a randomized controlled trial. Obstet Gynecol 125:1063-70
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Jelovsek, J Eric; Chagin, Kevin; Brubaker, Linda et al. (2014) A model for predicting the risk of de novo stress urinary incontinence in women undergoing pelvic organ prolapse surgery. Obstet Gynecol 123:279-87
Sung, Vivian W; Rogers, Rebecca G; Bann, Carla M et al. (2014) Symptom outcomes important to women with anal incontinence: a conceptual framework. Obstet Gynecol 123:1023-30