This application to the Global Network (GN) for Women's and Children's Research asks for the Global Network Research Unit of Aga Khan and Columbia Universities to be renewed for a third 5 year term. We believe that our track record, especially over the last 5 years, as documented in the full application, justifies an award for the next 5 years. The strengths of this application include a stable and highly productive team devoted to carrying out meaningful research to improve the health of women and children, large and varied populations for study, and an ongoing birth outcomes registry of 20 rural clusters of 500 deliveries per year each with excellent follow up. Pakistan, with a population of 180,000,000 people and some of the highest maternal, fetal and neonatal mortality rates anywhere in the world, provides every type of population that could be considered for GN studies. We have the largest number of rural clusters of any site in the GN with an active birth registry in each, and have also demonstrated access to a number of urban hospitals for deliveries and access to urban children for research purposes as well. To date we have recruited more than 220,000 subjects for GN studies. In the next 5 years, we plan to bring substantial external resources to the GN by building strong relationships between industry, foundations and the GN to do research meaningful to all three institutions. We will actively participate in the deliberations of the GN Steering Committee and continue to mentor more junior investigators at our site and other sites in the GN in research study design, and manuscript and grant preparation. One of our major goals is to improve facility performance in the care of mothers and infants. Our proposed common protocol alms to reduce facility fetal and neonatal mortality using a defined outcome related to facility care, e.g., the sum of intrapartum stillbirths and early (pre- discharg) neonatal deaths. Using a simple cellular telephone-based data collection system, rapid feedback on the defined outcome, and a quality assurance program aimed at reducing intrapartum related deaths;it is our hope to achieve a substantial improvement in facility-based pregnancy outcomes.

Public Health Relevance

This application is totally relevant to the mission of the Global Network. The major focus of our unit is to improve the health of pregnant women, their newborns, and children to age 3 in low and low middle income countries. We are committed to performing multicenter population-based interventional studies that provide important evidence leading to a reduction of maternal, perinatal and childhood mortality and morbidity.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Application #
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Koso-Thomas, Marion
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Columbia University (N.Y.)
Obstetrics & Gynecology
Schools of Medicine
New York
United States
Zip Code
Pasha, Omrana; Goudar, Shivaprasad S; Patel, Archana et al. (2015) Postpartum contraceptive use and unmet need for family planning in five low-income countries. Reprod Health 12 Suppl 2:S11
Dhaded, Sangappa M; Somannavar, Manjunath S; Vernekar, Sunil S et al. (2015) Neonatal mortality and coverage of essential newborn interventions 2010 - 2013: a prospective, population-based study from low-middle income countries. Reprod Health 12 Suppl 2:S6
Goldenberg, Robert L; McClure, Elizabeth M; Bose, Carl L et al. (2015) Research results from a registry supporting efforts to improve maternal and child health in low and middle income countries. Reprod Health 12:54
Goudar, Shivaprasad S; Derman, Richard J; Honnungar, Narayan V et al. (2015) An Intervention to Enhance Obstetric and Newborn Care in India: A Cluster Randomized-Trial. Matern Child Health J 19:2698-706
Goudar, Shivaprasad S; Stolka, Kristen B; Koso-Thomas, Marion et al. (2015) Data quality monitoring and performance metrics of a prospective, population-based observational study of maternal and newborn health in low resource settings. Reprod Health 12 Suppl 2:S2
Garces, Ana; Mcclure, Elizabeth M; Hambidge, K et al. (2015) Trends in perinatal deaths from 2010 to 2013 in the Guatemalan Western Highlands. Reprod Health 12 Suppl 2:S14
Bose, Carl L; Bauserman, Melissa; Goldenberg, Robert L et al. (2015) The Global Network Maternal Newborn Health Registry: a multi-national, community-based registry of pregnancy outcomes. Reprod Health 12 Suppl 2:S1
Harrison, Margo S; Ali, Sumera; Pasha, Omrana et al. (2015) A prospective population-based study of maternal, fetal, and neonatal outcomes in the setting of prolonged labor, obstructed labor and failure to progress in low- and middle-income countries. Reprod Health 12 Suppl 2:S9
Goudar, Shivaprasad S; Goco, Norman; Somannavar, Manjunath S et al. (2015) Institutional deliveries and perinatal and neonatal mortality in Southern and Central India. Reprod Health 12 Suppl 2:S13
Bauserman, Melissa; Lokangaka, Adrien; Thorsten, Vanessa et al. (2015) Risk factors for maternal death and trends in maternal mortality in low- and middle-income countries: a prospective longitudinal cohort analysis. Reprod Health 12 Suppl 2:S5

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