The objective of this proposal is to describe those attributes which support our site's ability to continue patient follow-up activities necessary for he successful completion of the phase III clinical trial evaluating creatine compared with placebo. Continued participation as a clinical trial site for this project allows our study team and currenty enrolled patients an opportunity to be part of the first long term study of PD patients at this stae of their illness.
Continuation of carrying out all patient follow-up activities will add valuable information to the body of data to be used in testing the primary hypothesis and secondary efficacy analyses planned in the LS-1 study.
|Wills, Anne-Marie A; PÃ©rez, Adriana; Wang, Jue et al. (2016) Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1 JAMA Neurol 73:321-8|
|Elm, Jordan J; NINDS NET-PD Investigators (2012) Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1. Mov Disord 27:1513-21|