The Neurodegeneration and Clinical Trials Group of the National Institute of Neurological Disorders and Stroke (NINDS) has issued a Request for Applications for Clinical Centers to collaborate in a large, double-blind, randomized trial of two or more potential neuroprotective agents in patients with early Parkinson's disease.
The specific aim of this application is to describe the characteristics of the Struthers Parkinson's Center that make it an appropriate and desirable site to participate in a multicenter trial of neuroprotective agents for Parkinson's disease. The Struthers Parkinson's Center, a National Parkinson Foundation Center of Excellence, is dedicated to research related to Parkinson's Disease and other Movement Disorders. This nationally recognized center offers an integrated approach to diagnosis, treatment and management with the most comprehensive clinical, therapeutic and support services available in the Upper Midwest. The Center looks forward to supporting this neuroprotective agent research effort for early stage Parkinson's disease. We have the patient population, institutional support, facilities, professional expertise, and enthusiasm necessary to serve as a Clinical Center in such a trial.
|Wills, Anne-Marie A; Elm, Jordan J; Ye, Rong et al. (2016) Cognitive function in 1736 participants in NINDS Exploratory Trials in PD Long-term Study-1. Parkinsonism Relat Disord 33:127-133|
|Wills, Anne-Marie A; Pérez, Adriana; Wang, Jue et al. (2016) Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1 JAMA Neurol 73:321-8|
|Sharp, Madeleine E; Caccappolo, Elise; Mejia-Santana, Helen et al. (2015) The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study. Mov Disord 30:278-83|
|Parashos, Sotirios A; Luo, Sheng; Biglan, Kevin M et al. (2014) Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience. JAMA Neurol 71:710-6|
|Elm, Jordan J; NINDS NET-PD Investigators (2012) Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1. Mov Disord 27:1513-21|