The NET-PD project is a collaborative effort including NINDS and approximately 50 other sites in North America to conduct clinical trials aimed at developing agents to prevent progression of Parkinson's disease (PD). Two futility studies (FS1, FS-TOO) of four compounds (coenzyme 010, creatine, GPI-1485, and minocycline) were completed in the initial stages of this project, leading to the ongoing LS1 study of creatine versus placebo. A third futility trial (FS-ZONE) has also been initiated comparing pioglitazone versus placebo. The LS1 study is expected to be completed in 2015, and the FS-ZONE study is expected to be completed in 2014. It is hoped that these trials will demonstrate pharmacologic benefits in both motor and non-motor features of PD, and additional knowledge will be gained about clinical trial development and PD in general.

Public Health Relevance

Short-term clinical management of early-stage PD (first 2-5 years after symptom onset) has been generally straightforward and beneficial. However, after this initial period of benefit, most patients begin to experience fluctuations in response to treatment. Efforts to prevent this manifestation of disease progression have been generally unsuccessful. The NET-PD project aims to coordinate a multicenter program to develop treatments to address disease progression in PD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10NS044555-11
Application #
8460317
Study Section
Special Emphasis Panel (ZNS1-SRB-B (34))
Program Officer
Moy, Claudia S
Project Start
2002-09-15
Project End
2015-11-30
Budget Start
2013-01-01
Budget End
2013-11-30
Support Year
11
Fiscal Year
2013
Total Cost
$47,260
Indirect Cost
$16,965
Name
Vanderbilt University Medical Center
Department
Neurology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
NINDS NET-PD Investigators (2008) A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results. Clin Neuropharmacol 31:141-50
Elm, Jordan J; Kamp, Cornelia; Tilley, Barbara C et al. (2007) Self-reported adherence versus pill count in Parkinson's disease: the NET-PD experience. Mov Disord 22:822-7