Neurolgical Emergencies Treatment Trials ( NETT ) research network was established to develop new therapies for acute neurological illness and injury. By bringing together likeminded and dedicated researchers at several academic institutions across the US, the NETT provides an efficient and effective means to rapidly study and advance the science needed for medical progress. This proposal is for renewal ofthe University of Minnesota NETT Hub . We currently have 9 Spokes , with recent additions increasing our catchment area to cover most population centers in our State. We engage at least 30 clinician investigators at these sites. We partner with state patient advocacy groups and include education and clinical outreach as well as research in our mission. As the coordinating center for several urban and rural, academic and community Spokes, the Minnesota Hub has promoted and provided successful Spoke development, and the recruitment and enrollment of patients into all NETT studies implemented so far, and looks forward to partipcation in future NETT clinical trials. The Minnesota Hub has used the lessons learned from one study to streamline the start up ofthe next. This includes , among others, the development of different models for Hub support of Spokes, a "one number" alert system to deploy an on- call Hub research team, an IRB approved prototype for rapid evaluation and implementation of Exception from Informed Consent ( EFIC) studies, exploration of telemedicine for enrollment and consent of patients at remote sites, creative budgeting to ensure adequate reimbursment for certification and training time for Spoke investigators, and a secure storage cabinent and tracking system for study drugs used out of hospital.
The specific aims of this proposal are; 1) to use lessons learned to efficiently implement additonal ( 4-7 ) trials performed by the NETT 2) to actively develop exisitng and new spokes and investigators in their independent research capacities 3) to serve as a state wide resource for patients and the neuroscience and emergency medical communities

Public Health Relevance

Research to advance the treatment of acute neurological emergencies has been hampered by their relatively infrequent occurance. The NETT provides the opportunity to hasten discovery by increasing the ability to conduct relevant studies across multiple sites and patient populations. The Minnesota Hub will contribute to this mission by meeting and maintaining NETT research goals .while fostering community involvement in research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10NS058994-07
Application #
8539086
Study Section
Special Emphasis Panel (ZNS1-SRB-N (01))
Program Officer
Janis, Scott
Project Start
2007-05-03
Project End
2017-05-31
Budget Start
2013-08-01
Budget End
2014-05-31
Support Year
7
Fiscal Year
2013
Total Cost
$301,328
Indirect Cost
$116,586
Name
University of Minnesota Twin Cities
Department
Emergency Medicine
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Biros, Michelle H; Sargent, Corey; Miller, Kathleen (2009) Community attitudes towards emergency research and exception from informed consent. Resuscitation 80:1382-7