Our objective is to participate in the Neurological Emergencies Treatment Trials (NETT) network in order to improve outcomes for patients with neurological emergencies. Our goals align with those of the NETT. The NETT Southeastern Collaborative will 1) facilitate high-quality clinical trials in a wide variety of neurological diseases (cerebrovascular disorders, epileptic seizures, acute infections of the CNS, acute neuromuscular disorders and trauma) in adults or children;2) build on existing and create new collaborations between emergency medicine physicians, neurologists, neurosurgeons, trauma specialists, neuroradiologists, and neuro-intensivists in the development and conduct of clinical trials, 3) facilitate the implementation of new therapies into clinical practice by active collaborations with community and local hospitals. We have active collaborations with many of these hospitals, a majority of which have emergency medicine and neurology faculty residency trained at our own program at Emory University.
Our Specific Aims are: 1. To develop an infrastructure to conduct clinical trials in neurological emergencies. 2. To develop a regional collaborative network of high volume hospitals capable of conducting efficient and high quality clinical trials. 3. To recruit a broad range of participants, particularly minorities. 4. To facilitate the transfer of research results to clinical practice, especially to community hospital settings, and the general endorsement by emergency medicine physicians. The NETT SEC brings together an extensive array of high volume urban and sub-urban hospitals with a well established tract record of expertise and experience in conducting ground breaking research in neurological emergencies in a multiracial region.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZNS1-SRB-K (41))
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Janis, Scott
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Emory University
Emergency Medicine
Schools of Medicine
United States
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Whitesides, Louisa W; Baren, Jill M; Biros, Michelle H et al. (2017) Impact of individual clinical outcomes on trial participants' perspectives on enrollment in emergency research without consent. Clin Trials 14:180-186
Scicluna, Victoria M; Ali, Mohammed K; Pentz, Rebecca D et al. (2017) Does experience matter? Implications for community consultation for research in emergency settings. AJOB Empir Bioeth 8:75-81
Denninghoff, Kurt R; Nuño, Tomas; Pauls, Qi et al. (2017) Prehospital Intubation is Associated with Favorable Outcomes and Lower Mortality in ProTECT III. Prehosp Emerg Care 21:539-544
Goldstein, Felicia C; Caveney, Angela F; Hertzberg, Vicki S et al. (2017) Very Early Administration of Progesterone Does Not Improve Neuropsychological Outcomes in Subjects with Moderate to Severe Traumatic Brain Injury. J Neurotrauma 34:115-120
Sribnick, Eric Anthony; Shi, Junxin; Lunney, Michael P et al. (2016) 379?Communicating a Traumatic Brain Injury Patient's Potential Need for Operative Intervention: The Surgical Intervention for Traumatic Injury Scale. Neurosurgery 63 Suppl 1:213
Dickert, Neal W; Brown, Jeremy; Cairns, Charles B et al. (2016) Confronting Ethical and Regulatory Challenges of Emergency Care Research With Conscious Patients. Ann Emerg Med 67:538-45
Dickert, Neal W; Scicluna, Victoria M; Baren, Jill M et al. (2015) Patients' perspectives of enrollment in research without consent: the patients' experiences in emergency research-progesterone for the treatment of traumatic brain injury study. Crit Care Med 43:603-12
Wright, David W; Yeatts, Sharon D; Silbergleit, Robert et al. (2014) Very early administration of progesterone for acute traumatic brain injury. N Engl J Med 371:2457-66
Menon, David K; Schwab, Karen; Wright, David W et al. (2010) Position statement: definition of traumatic brain injury. Arch Phys Med Rehabil 91:1637-40