Our center for 25 years has been a leader in clinical trials testing new treatments for stroke and brain hemorrhage. In this application, we aim to serve as a leading regional stroke coordinating center in the NINDS clinical trials stroke network and have assembled a well-organized group of connected clinical sites linked by a history of productive collaboration and led by a multidisciplinary and ethnically diverse team.
In Specific Aim 1, we intend to lead a regional stroke coordinating center (RCC) consisting of multidisciplinary teams to conduct clinical trials testing novel stroke therapies in acute stroke, stroke prevention, and stroke recovery. The UT-Houston RCC will conduct clinical trials within a network of inter-connected sites in the greater Houston area, San Antonio, and New Orleans involving both adult and pediatric patients with attention to the recruitment of minorities and women.
In specific Aim 2, we will provide expertise and leadership for the design of novel trials and propose trials testing new stroke therapies in acute stroke, stroke prevention, and stroke recovery. We will also provide translational expertise for the development of new stroke therapies from bench to bedside and for the development and testing of novel biomarkers.
In specific Aim 3, we will establish a training program within our network for clinician-scientists wih high potential for independent research careers in stroke.

Public Health Relevance

Stroke is the leading cause of adult disability. A range of therapies are urgently needed to treat, prevent and promote recovery from stroke. We aim to serve as a regional coordinating center to conduct clinical trials in a network consisting ofthe stroke programs at UT-HEALTH, UT-San Antonio, and Tulane School of Medicine. Our consortium for clinical trials covers South Texas, the Gulf Coast, and Louisiana. PROJECT/PERFORMANCE S|TE(S) (if additional space is needed, use

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
1U10NS086496-01
Application #
8662427
Study Section
Special Emphasis Panel (ZNS1-SRB-G (68))
Program Officer
Vivalda, Joanna
Project Start
2013-09-30
Project End
2018-07-31
Budget Start
2013-09-30
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$380,000
Indirect Cost
$130,000
Name
University of Texas Health Science Center Houston
Department
Neurology
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225