The objectives of the proposed NINDS Stroke Clinical Trials Network (NSTN) are to harness multidisciplinary stroke expertise to collaboratively and efficiently design and execute stroke clinical trials in all phases. We will bring a fully integratd clinical trial network approach to stroke more broadly and cohesively as a Regional Coordinating Center (RCC) of the NSTN. Our goals are to (1) efficiently implement trials, recruit and retain participants, and optimize data quality as an RCC, (2) actively participate in the NSTN as experienced scientists, clinicians, trialists, and coordinators, and (3) successfully train the next generation of stroke clinical trialists. We will achieve these goals by bringing experienced leadership, access to a diverse patient population, an established research infrastructure, and a supportive administration. Our institution has shown their commitment to the NSTN by agreeing to use a standardized Master Trial Agreement, employ a centralized IRB review, and provide additional institutional funds to support the RCC trainee. We propose to be a key partner in the NSTN working to bring the most clinically impactful stroke therapies to our patients through high-quality stroke trials.

Public Health Relevance

Stroke is a public health priority as a leading cause of death and disability worldwide. Multicenter clinical trials are needed to test new discoveries that may reduce this burden in the treatment, prevention, and recovery arenas. The proposed Cincinnati RCC will partner with the NINDS Stroke Trials Network to improve clinical trial efficiency, success, and quality and thereby advance stroke care for our patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
1U10NS086512-01
Application #
8662833
Study Section
Special Emphasis Panel (ZNS1-SRB-G (68))
Program Officer
Vivalda, Joanna
Project Start
2013-09-30
Project End
2018-07-31
Budget Start
2013-09-30
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$396,250
Indirect Cost
$146,250
Name
University of Cincinnati
Department
Neurology
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221