We have strengthened our revised proposal in several major ways. First, we have expanded our genetic sequencing of the extreme phenotype of centenarians (with appropriate controls) to include the entire human exome, in addition to regulatory/conserved regions of more genes (~1,000) selected by our Scientific Advisory Committee, based on work from model systems and previous genome-wide association studies (GWAS) for longevity. Second, instead of creating a Gene Function Core, we will analyze and characterize in silico the variants we discover in order to identify the best candidates for subsequent functional studies. Third, after careful consideration of reviewers'comments and concerns about the proposed in vitro work, we decided to defer several proposals for in vitro studies of specific pathways-insulin signaling, TOR, mitochondria and energy-sensing, micro- and regulatory RNA, and proteostasis?until we have identified the best candidates for functional studies. In addition, we have modified the remaining projects and cores in response to the previous reviews. We are excited that the next phase of the Longevity Consortium (LC) will have a substantial impact on research on aging and chronic degenerative diseases.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAG1-ZIJ-5 (03))
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Rossi, Winifred K
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California Pacific Medical Center Research Institute
San Francisco
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Dostál, Lubomír; Kohler, William M; Penner-Hahn, James E et al. (2015) Fibroblasts from long-lived rodent species exclude cadmium. J Gerontol A Biol Sci Med Sci 70:9-Oct
Broer, Linda; Buchman, Aron S; Deelen, Joris et al. (2015) GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci 70:110-8
Kaufman, Laura B; Setiono, Tiffany K; Doros, Gheorghe et al. (2014) An oral health study of centenarians and children of centenarians. J Am Geriatr Soc 62:1168-73
Arum, Oge; Rickman, Dustin J; Kopchick, John J et al. (2014) The slow-aging growth hormone receptor/binding protein gene-disrupted (GHR-KO) mouse is protected from aging-resultant neuromusculoskeletal frailty. Age (Dordr) 36:117-27
Nievergelt, Caroline M; Wineinger, Nathan E; Libiger, Ondrej et al. (2014) Chip-based direct genotyping of coding variants in genome wide association studies: utility, issues and prospects. Gene 540:104-9
Arum, Oge; Saleh, Jamal K; Boparai, Ravneet K et al. (2014) Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age. Age (Dordr) 36:9651
Scott-Van Zeeland, A A; Bloss, C S; Tewhey, R et al. (2014) Evidence for the role of EPHX2 gene variants in anorexia nervosa. Mol Psychiatry 19:724-32
An, Ping; Miljkovic, Iva; Thyagarajan, Bharat et al. (2014) Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). Metabolism 63:461-8
Peng, Qian; Gizer, Ian R; Libiger, Ondrej et al. (2014) Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. Am J Med Genet B Neuropsychiatr Genet 165B:673-83
Huckins, Laura M; Boraska, Vesna; Franklin, Christopher S et al. (2014) Using ancestry-informative markers to identify fine structure across 15 populations of European origin. Eur J Hum Genet 22:1190-200

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