Core A: Administration will serve as the Coordinating Center for the entire DIAN project. As such, the specific aims of Core A: Administration are as follows: 1. Organize and coordinate activities and communication of the Cores, subcontractors and clinical performance sites toward achieving the stated goals of DIAN, to include administrative, and budgetary support and monitoring, and problem solving on a continuous basis. 2. With the Clinical Core and the Clinical Coordinating Center, delineate protocols;establish, coordinate and monitor participant recruitment and retention. 3. With the Clinical Core, the Clinical Coordinating Center, the Genetics Core and the Informatics Core, organize and monitor data and tissue collection, and storage. 4. With the Steering Committee and subcommittees, establish policies and procedures regarding: protection of research participants;resource (data, images and tissue) sharing, dissemination, an publications;and future expansion of DIAN to include other sites and languages. 5. Organize and support the DIAN Steering Committee and its subcommittees to include arranging meetings, communication and execution of their decisions. 6. Arrange for periodic external review and advice concerning DIAN goals and progress 7. Arrange for and finance genetic counseling and testing services when desired, and participant travel when necessary for participation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AG032438-05
Application #
8424998
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1)
Project Start
Project End
Budget Start
2013-01-01
Budget End
2013-12-31
Support Year
5
Fiscal Year
2013
Total Cost
$1,093,526
Indirect Cost
$227,886
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Su, Yi; Blazey, Tyler M; Snyder, Abraham Z et al. (2015) Partial volume correction in quantitative amyloid imaging. Neuroimage 107:55-64
Fagan, Anne M; Xiong, Chengjie; Jasielec, Mateusz S et al. (2014) Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Sci Transl Med 6:226ra30
Xiong, Chengjie; Luo, Jingqin; Gao, Feng et al. (2014) Optimizing parameters in clinical trials with a randomized start or withdrawal design. Comput Stat Data Anal 69:101-113
Brier, Matthew R; Thomas, Jewell B; Snyder, Abraham Z et al. (2014) Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging. Neurology 83:1613-9
Xiong, Chengjie; Weng, Hua; Bennett, David A et al. (2014) Subsets of a large cognitive battery better power clinical trials on early stage Alzheimer's disease. Neuroepidemiology 43:131-9
Storandt, Martha; Balota, David A; Aschenbrenner, Andrew J et al. (2014) Clinical and psychological characteristics of the initial cohort of the Dominantly Inherited Alzheimer Network (DIAN). Neuropsychology 28:19-29
Ting, Simon Kang Seng; Benzinger, Tammie; Kepe, Vladimir et al. (2014) A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman. J Alzheimers Dis 40:271-5
Gordon, Brian A; Blazey, Tyler; Benzinger, Tammie Ls (2014) Regional variability in Alzheimer's disease biomarkers. Future Neurol 9:131-134
Ryman, Davis C; Acosta-Baena, Natalia; Aisen, Paul S et al. (2014) Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology 83:253-60
Dobrowolska, Justyna A; Kasten, Tom; Huang, Yafei et al. (2014) Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system. PLoS One 9:e89998

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