The Biostatistics Core (Core C) will bridge the transition from the DIAN database stored and managed by the Informatics Core (Core H) to the analyses of the longitudinal data within, between, and among the various data domains, the latter of which serves as the primary responsibility of the Core. Specifically the Biostatistics Core will: (1) oversee the statistical quality control of data for the study and produce appropriately de-identified and statistically analyzable datasets for distribution/analysis;(2) lead the statistical data analyses and collaborate in report preparation for all Cores and projects, and consult on the design of all projects and on the application of appropriate statistical and methodological techniques;(3) develop and implement appropriate statistical models for longitudinal changes in potential markers and use these models to test the statistical hypotheses about the preclinical changes of AD and about the temporal difference on preclinical changes of AD among various markers, and (4) serve as an advisory group for other researchers interested in using the DIAN database for additional analyses. The Biostatistics core will achieve these specific aims through extensive interactions and collaborations with all other components of DIAN.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AG032438-05
Application #
8425001
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1)
Project Start
Project End
Budget Start
2013-01-01
Budget End
2013-12-31
Support Year
5
Fiscal Year
2013
Total Cost
$56,334
Indirect Cost
$11,959
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Su, Yi; Blazey, Tyler M; Owen, Christopher J et al. (2016) Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group. PLoS One 11:e0163669
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