This is a competing renewal for a Sexually Transmitted Infections Cooperative Research Center (STI ORG). The Southeastern STI ORG is comprised of six projects Including studies on the sexually transmitted pathogens Neisseria gonorrhoeae and Haemophilus ducreyi. Five synergistic projects explore molecular pathogenesis, immunobiology and possible vaccines for gonorrhea, and the sixth project focuses on development of a promising vaccine for H. ducreyi. The six projects are supported by an Administrative Core, a Microbiology Core and an Immunology Core. Project 1 uses the murine model of gonococcal infection to study mucosal vaccine candidates. Project 2 focuses on iron-regulated adherence factors of N. gonorrhoeae. Project 3 deals with genetic mechanisms of gonococcal resistance to mediators of innate immunity. Project 4 aims at preventing gonococcal infection by targeting the adherence factor PilG. Project 5 centers on innate host immune responses to gonococcal infection. Project 6 focuses on the H. ducreyi outer membrane protein DsrA as a chancroid vaccine using a swine model of infection. The Microbiology Core will conduct experimental human gonococcal infection experiments in support of Projects 2-5. The Immunology Core provides expertise In mucosal adjuvants and immunization protocols for gonococcal studies in mice and chancroid studies in pigs and sophisticated immune monitoring using specimens from animals and humans. The overall theme uniting these projects and cores is New Approaches to STI Prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI031496-21
Application #
8138522
Study Section
Special Emphasis Panel (ZAI1-MMT-M (M1))
Program Officer
Rogers, Elizabeth
Project Start
1997-07-01
Project End
2014-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
21
Fiscal Year
2011
Total Cost
$2,649,057
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Gallo, Maria F; Legardy-Williams, Jennifer; Steiner, Markus J et al. (2017) Sexual Relationship Power and Semen Exposure Among Female Patients at a Sexually Transmitted Infection Clinic in Kingston, Jamaica. Arch Sex Behav 46:2157-2164
Woolf-King, Sarah E; Muyindike, Winnie; Hobbs, Marcia M et al. (2017) Vaginal Prostate Specific Antigen (PSA) Is a Useful Biomarker of Semen Exposure Among HIV-Infected Ugandan Women. AIDS Behav 21:2141-2146
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Sanders, Eduard J; Wahome, Elizabeth; Powers, Kimberly A et al. (2015) Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa. AIDS 29 Suppl 3:S221-30
Ohneck, Elizabeth A; Goytia, Maira; Rouquette-Loughlin, Corinne E et al. (2015) Overproduction of the MtrCDE efflux pump in Neisseria gonorrhoeae produces unexpected changes in cellular transcription patterns. Antimicrob Agents Chemother 59:724-6
Unemo, Magnus; Shafer, William M (2015) Future treatment of gonorrhea--novel emerging drugs are essential and in progress? Expert Opin Emerg Drugs 20:357-60

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