Food allergy affects over 11 million Americans and is most prevalent in young children, with 6% - 8% of children less than 3 years of age experiencing some form of food hypersensitivty. Milk allergy is the most common cause of food hypersensitivity in infants and young children, typically develops in the first year of life, affects 2.5% of infants in industrialized countries, and is "outgrown" in about 80% of children by 6 years of age. IgE-mediated allergy accounts for about 70% of milk allergic disorders, i.e. 1.8% of young infants, and often is a harbinger of future atopic disorders and other food allergies.Despite an increased understanding of IgE-mediated immunopathology, no successful therapeutic measures have been developed to prevent or reverse food allergies. The overall goal of this Center is to elucidate further underlying immunologic mechanisms of milk allergy and to develop safe and effective forms of therapy. The Administrative Core will facilitate this effort by providing the organizational backbone for this Center, monitoring clincal trials, providing biostatistical support for all projects, and coordinating interactions within and outside the Center, e.g. NIAID, other AADCR Centers and the external Scientific Review Committee. This wll be achieved through the following Specific Aims:
Aim #1 : Facilitate communication and interaction between Projects 1-3, assist in subject recruitment and retention, and provide clinical monitoring, database support and biostatistical support for all projects.
Aim #2 : Implement an external Scientific Review Committee with independent experts in the field of food allergy and immunotherapy.
Aim #3 : Provide mechanisms for communicating with other members of the AADCR Centers.
Aim #4 : Oversee resource and data sharing between this project and other members of the AADCR Centers. The Administrative Core will provide manegerial support, organizational support for monthly internal project review meetings, quarterly inter-project meetings of Pi's and key personnel, quarterly AADCRC Steering Committee teleconferences, bienniel Scientific Advisory Committee teleconferences, and annual AADCRC PI meetings in Bethesda. The Core will arrange lodging [if nececessary;e.g. external reviewers], meeting rooms and equipment for meetings held at Mount Sinai, and process travel expense reports for reimbursement to scientific and PI annual meetings. The Core will also work with the AADCRC Steering Committee to promote the sharing of data collected as a part of this proposal and of methods, procedures and resources developed in support of this proposal with other members of the AADCRC network.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
3U19AI044236-14S1
Application #
8627267
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
Project End
2015-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
14
Fiscal Year
2013
Total Cost
$63,615
Indirect Cost
$26,084
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
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Jarvinen, K M; Westfall, J E; Seppo, M S et al. (2014) Role of maternal elimination diets and human milk IgA in the development of cow's milk allergy in the infants. Clin Exp Allergy 44:69-78
Caubet, Jean-Christoph; Nowak-Wegrzyn, Anna; Moshier, Erin et al. (2013) Utility of casein-specific IgE levels in predicting reactivity to baked milk. J Allergy Clin Immunol 131:222-4.e1-4
Blazquez, Ana Belen; Knight, Adina Kay; Getachew, Hoheteberhan et al. (2010) A functional role for CCR6 on proallergic T cells in the gastrointestinal tract. Gastroenterology 138:275-84.e1-4
Savilahti, Emma M; Rantanen, Ville; Lin, Jing S et al. (2010) Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes. J Allergy Clin Immunol 125:1315-1321.e9
Shreffler, Wayne G; Wanich, Niya; Moloney, Marla et al. (2009) Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol 123:43-52.e7
Skripak, Justin M; Sampson, Hugh A (2008) Towards a cure for food allergy. Curr Opin Immunol 20:690-6