The Administrative Core of the Duke Autoimmunity Center of Excellence (ACE) will provide leadership and support for the two basic research projects, the Pilot Research Project (if approved), the 5 ongoing clinical trials, and any new clinical trials approved by ACE Steering Committee. Its overarching goal will be to promote the objectives of this integrated basic and clinical research program, ensure the quality and progress of the individual funded projects, foster interactions among basic and clinical scientists, and facilitate the appropriate dissemination of research findings. The core will be under the direction of Dr. E. William St.Clair (Principal Investigator) who will also serve as the Clinical Research Representative. He will be responsible for overseeing all budgetary matters of the Duke ACE, organizing monthly meetings of the Executive Committee, arranging for the twice yearly ACE research meetings, and coordinating the preparation of non-competitive renewal applications. Dr. Tedder will serve as the Associate Director and Basic Research Representative of the Administrative Core and work closely with Dr. St.Clair in managing the ACE research enterprise, ensuring program relevance, and facilitating interactions between the basic and clinical scientists. Tammy Caudil (Department of Immunology) and Patty Might Davis (Division of Rheumatology and Immunology) will provide administrative support for the core. Together, they will adminstrate the fmaces, coordinate meetings, interface with NIAID staff and the institution responsible for the management of the ACE Discretionary Fund. The core will also utilize an Executive Committee to ensure effective management and integration of the projects, as well as coordinate an annual review of the resarch activities by the Duke ACE Advisory Board. Drs. St.Clair and Tedder will be joined on the Executive committee by Drs. Garnett Kelsoe, Russell Hall, and David Pisetsky. The Core will also support educational activities to enhance the visibility of the Center within Duke and provide a forum for communicating and exchanging research ideas. The Administrative Core will nurture a vibrant, interactive program of clinical and basic research that will advance our understanding about the role of B cells in autoimmune disease.

Public Health Relevance

The Administrative Core of the will support the basic and clinical research activities of the Duke Autoimmunity Center of Excellence and be led by Dr. E. William St.Clair (Director, Clinical Research Representative) and Dr. Thomas F. Tedder (Associate Director, Basic Research Representative). It will oversee all budgetary aspects of the Duke ACE and ensure the quality and progress of the projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI056363-10
Application #
8466198
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
10
Fiscal Year
2013
Total Cost
$121,206
Indirect Cost
$32,091
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Su, Kuei-Ying; Watanabe, Akiko; Yeh, Chen-Hao et al. (2016) Efficient Culture of Human Naive and Memory B Cells for Use as APCs. J Immunol 197:4163-4176
Cui, Ang; Di Niro, Roberto; Vander Heiden, Jason A et al. (2016) A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data. J Immunol 197:3566-3574
Cao, Yonghao; Amezquita, Robert A; Kleinstein, Steven H et al. (2016) Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production. J Immunol 196:2075-84
Haddon, David James; Jarrell, Justin Ansel; Diep, Vivian K et al. (2015) Mapping epitopes of U1-70K autoantibodies at single-amino acid resolution. Autoimmunity 48:513-23
Kountikov, Evgueni I; Poe, Jonathan C; Maclver, Nancie J et al. (2015) A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. Am J Pathol 185:617-30
Hall 3rd, R P; Fairley, J; Woodley, D et al. (2015) A multicentre randomized trial of the treatment of patients with pemphigus vulgaris with infliximab and prednisone compared with prednisone alone. Br J Dermatol 172:760-8
Aranow, Cynthia; Kamen, Diane L; Dall'Era, Maria et al. (2015) Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus. Arthritis Rheumatol 67:1848-57
Nair, Nitya; Mei, Henrik E; Chen, Shih-Yu et al. (2015) Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy. Arthritis Res Ther 17:127
Ci, Xinxin; Kuraoka, Masayuki; Wang, Hongxia et al. (2015) TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. PLoS One 10:e0127527
Labowsky, Michael; Lowenthal, Justin; Fahmy, Tarek M (2015) An in silico analysis of nanoparticle/cell diffusive transfer: application to nano-artificial antigen-presenting cell:T-cell interaction. Nanomedicine 11:1019-28

Showing the most recent 10 out of 141 publications