The University of Rochester Autoimmunity Center of Excellence will conduct basic and clinical research that investigates the cause of human autoimmunity and searches for improved and safer treatment modalities. The function of this Administrative Core A will be to provide support, organization, coordination and efficient management of the ACE. The goals of this Core are: 1. To provide oversight and guidance to all components and investigators of the ACE in order to ensure proper and timely fiscal management and use of human and financial resources. 2. To ensure that all investigators and support personnel are trained and accredited by the UR Research Subject Review Board (RSRB) and that such training and accreditation is current as mandated by RSRB guidelines. The critical corollary is that, together with the Clinical Component Leadership, the most important objective of this core will be to ensure patients safety and confidentiality. 3. To facilitate the interaction between the Rochester ACE, the organizing center and the ACE Steering Committee. 4. To maximize the coordination and scientific progress all projects. These goals will be accomplished through close interaction between Drs. Sanz and Looney who will also serve as the Research and Clinical Representatives, respectively, to the Steering Committee. They will work with the Core Administrator (Ms. Lamendola) who will oversee grant accounting support personnel and provide the liaison between the ACE, the NIH and the University of Rochester Office of Research Administration. Drs. Sanz and Looney will work together to ensure productivity and interactions among investigators and most importantly, to ensure patients safety and confidentiality. Ms. Lamendola will supervise the preparation and distribution of financial and administrative reports, develop and monitor budgets;monitor expenses against budgets ensuring expenditures are allowable, allocable, reasonable, and properly authorized. This structure will provide indispensable fiscal oversight and help with timely execution

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI056390-09
Application #
8376336
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
9
Fiscal Year
2012
Total Cost
$85,933
Indirect Cost
$20,727
Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Misra, Ravi S; Shah, Syed; Fowell, Deborah J et al. (2015) Preterm cord blood CD4⁺ T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4⁺ T cells in bronchopulmonary dysplasia. Hum Immunol 76:329-38
Chara, Luis; Sánchez-Atrio, Ana; Pérez, Ana et al. (2015) The number of circulating monocytes as biomarkers of the clinical response to methotrexate in untreated patients with rheumatoid arthritis. J Transl Med 13:2
Adlowitz, Diana G; Barnard, Jennifer; Biear, Jamie N et al. (2015) Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response. PLoS One 10:e0128269
Halliley, Jessica L; Tipton, Christopher M; Liesveld, Jane et al. (2015) Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow. Immunity 43:132-45
Wei, Chungwen; Jenks, Scott; Sanz, Iñaki (2015) Polychromatic flow cytometry in evaluating rheumatic disease patients. Arthritis Res Ther 17:46
Kobie, James J; Treanor, John J; Ritchlin, Christopher T (2014) Transient decrease in human peripheral blood myeloid dendritic cells following influenza vaccination correlates with induction of serum antibody. Immunol Invest 43:606-15
Zhang, Hengwei; Hilton, Matthew J; Anolik, Jennifer H et al. (2014) NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB. J Clin Invest 124:3200-14
Segal, Benjamin M (2014) Stage-specific immune dysregulation in multiple sclerosis. J Interferon Cytokine Res 34:633-40
Palanichamy, Arumugam; Bauer, Jason W; Yalavarthi, Srilakshmi et al. (2014) Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus. J Immunol 192:906-18
Roberts, Mustimbo E P; Kaminski, Denise; Jenks, Scott A et al. (2014) Primary Sjögren's syndrome is characterized by distinct phenotypic and transcriptional profiles of IgD+ unswitched memory B cells. Arthritis Rheumatol 66:2558-69

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