ADMINISTRATIVE CORE for Influenza Immunity: Protective Mechanisms against a Pandemic Respiratory Virus. The Administrative Core of the Stanford Cooperative Center for Translational Research on Human Immunology and Biodefense will oversee the conduct of the research projects, technology development projects, pilot projects, and scientific cores proposed here. The Administrative Core will be led by Dr. Mark Davis as PI, with Drs. Ann Arvin and Harry Greenberg as co-Pis;they will anchor the Executive Committee, with the other project directors Drs. Nolan, Quake, and Butte as members. In addition, two other senior investigators from Stanford's School of Medicine will be recruited to serve on the Executive Committee on a rotating basis for two year terms.
The Specific Aims of the Adminstrative Core are to: 1) Implement administrative &leadership mechanisms that will facilitate communication and cooperation among the Stanford project leaders and with other CCHI investigators institutions to ensure a productive research effort; 2) Monitor the progress of each of the Research and Technology Development projects and their interactions with the scientific cores; 3) Provide an efficient, centralized unit for the fiscal and administrative operation of the Cooperative Center activities; 4) Develop, sponsor, and manage the Education Program. The Administrative Core personnel will be responsible for the overall organization, management, decision-making, and periodic evaluations within Stanford's CCHI. In addition, they will also oversee data sharing, protection of intellectual property in conjunction with Stanford's Office of Technology Licensing, and the involvement of institutional resources such as the GCRC.
Annual influenza epidemics are a serious public health problem;influenza pandemics are a major threat. It is important to have an efficient administrative core component to maximize use of scarce research resources which are required to develop new knowledge about the human immune response to influenza vaccines and how these responses protect against infection.
|Krishnaswamy, Smita; Spitzer, Matthew H; Mingueneau, Michael et al. (2014) Systems biology. Conditional density-based analysis of T cell signaling in single-cell data. Science 346:1250689|
|Bendall, Sean C; Davis, Kara L; Amir, El-Ad David et al. (2014) Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell 157:714-25|
|Gaudillière, Brice; Fragiadakis, Gabriela K; Bruggner, Robert V et al. (2014) Clinical recovery from surgery correlates with single-cell immune signatures. Sci Transl Med 6:255ra131|
|Sen, Adrish; Rott, Lusijah; Phan, Nguyen et al. (2014) Rotavirus NSP1 protein inhibits interferon-mediated STAT1 activation. J Virol 88:41-53|
|Furman, David; Hejblum, Boris P; Simon, Noah et al. (2014) Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. Proc Natl Acad Sci U S A 111:869-74|
|Sen, Nandini; Mukherjee, Gourab; Sen, Adrish et al. (2014) Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus. Cell Rep 8:633-45|
|Pernas, Lena; Ramirez, Raymund; Holmes, Tyson H et al. (2014) Immune profiling of pregnant Toxoplasma-infected US and Colombia patients reveals surprising impacts of infection on peripheral blood cytokines. J Infect Dis 210:923-31|
|Bruggner, Robert V; Bodenmiller, Bernd; Dill, David L et al. (2014) Automated identification of stratifying signatures in cellular subpopulations. Proc Natl Acad Sci U S A 111:E2770-7|
|Chang, Serena; Kohrt, Holbrook; Maecker, Holden T (2014) Monitoring the immune competence of cancer patients to predict outcome. Cancer Immunol Immunother 63:713-9|
|Birnbaum, Michael E; Mendoza, Juan L; Sethi, Dhruv K et al. (2014) Deconstructing the peptide-MHC specificity of T cell recognition. Cell 157:1073-87|
Showing the most recent 10 out of 64 publications