Core C1: The Clinical/Statistical Core serves to support the three research projects and the technology development project of the U19 research program. The research projects described elsewhere are focused on immunological responses to yellow fever virus (YFV) vaccination and dengue infection. Specifically, they will evaluate human immune memory, innate immunity, and immunological senescence to these viruses, while the technology development project will study effector and memory B cells and create novel monoclonal antibody reagents targeting these same pathogens. The clinical core has four specific aims: 1) To provide clinical study expertise and capacity to ensure the success of the U19 scientific agenda. The support activities to be provided include: study design;clinical protocol and informed consent form preparation;obtaining required regulatory approvals;outreach and education with communities in which recruiting will occur;recruitment, screening, and enrollment;clinical study conduct according to Good Clinical Practice (GCP) standards;volunteer safety monitoring;clinical specimen collection, processing, tracking, storage, and shipping;preparation of progress reports, final report, presentations, and publications. 2) To provide statistical and data management expertise that ensures the success of the U19 scientific agenda. The support activities to be provided include: consultation on study design, sample size calculation, protocol writing, data management, descriptive statistics for studies, data analysis, preparation of progress reports, final reports, presentations, and publications. 3) To perform clinical studies with YFV vaccine that will provide the clinical specimens and data necessary to accomplish the scientific aims of the research and technology development projects. 4) To perform a clinical study of natural dengue infection that will provide the clinical specimens and data necessary to accomplish the scientific aims of the research and technology development projects.
The work proposed is directly relevant to the health of the public. Vaccines have been our most effective weapons to battle infectious diseases and protect public health. The work proposed will lead to better understanding of the immunological mechanisms that make a good vaccine successful (YFV) and will generate new knowledge of immunity to dengue infection, where new vaccines are needed.
|Kim, C; Fang, F; Weyand, C M et al. (2017) The life cycle of a T cell after vaccination - where does immune ageing strike? Clin Exp Immunol 187:71-81|
|Goronzy, Jörg J; Weyand, Cornelia M (2017) Successful and Maladaptive T Cell Aging. Immunity 46:364-378|
|Wang, Taia T; Sewatanon, Jaturong; Memoli, Matthew J et al. (2017) IgG antibodies to dengue enhanced for Fc?RIIIA binding determine disease severity. Science 355:395-398|
|Kazmin, Dmitri; Nakaya, Helder I; Lee, Eva K et al. (2017) Systems analysis of protective immune responses to RTS,S malaria vaccination in humans. Proc Natl Acad Sci U S A 114:2425-2430|
|Yan, Yan; Qiu, Shangzhao; Jin, Zhuxuan et al. (2017) Detecting subnetwork-level dynamic correlations. Bioinformatics 33:256-265|
|Litzenburger, Ulrike M; Buenrostro, Jason D; Wu, Beijing et al. (2017) Single-cell epigenomic variability reveals functional cancer heterogeneity. Genome Biol 18:15|
|Bowen, James R; Quicke, Kendra M; Maddur, Mohan S et al. (2017) Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells. PLoS Pathog 13:e1006164|
|Corces, M Ryan; Trevino, Alexandro E; Hamilton, Emily G et al. (2017) An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nat Methods 14:959-962|
|Yanes, Rolando E; Gustafson, Claire E; Weyand, Cornelia M et al. (2017) Lymphocyte generation and population homeostasis throughout life. Semin Hematol 54:33-38|
|Schep, Alicia N; Wu, Beijing; Buenrostro, Jason D et al. (2017) chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data. Nat Methods 14:975-978|
Showing the most recent 10 out of 227 publications