The Genomics and Computational Biology Core provides a critical means by which this U19 will achieve its goal of understanding the human innate and adaptive response to Yellow Fever Virus (YFV) in the young and aged. The Core will provide expertise, computational support and novel gene expression analysis technologies to enable the experiments detailed in this proposal. The Core will be centered at Dana-Farber Cancer Institute (DFCI), a leading institution in the application of genomic technologies, and include expert computational support from the Broad Institute of Harvard and MIT, and Georgia Institute of Technology. The Core will serve two primary functions. First, it will generate genomic data using a highthroughput expression profiling platform developed by our group that allows large numbers of samples to be profiled at low cost. It will also provide training for Project sites to generate genomic data from rare populations of cells using optimized RNA amplification approaches. Second, the Core will assist the projects to provide centralized design, development and analysis of genomicbased research that is instrumental to the projects.

Public Health Relevance

The Projects in this U19 will rely heavily on a range of genomics technologies to interrogate the innate and adaptive response to YFV in humans. The Genomics and Computational Biology Core will provide the analytic and experimental tools that will enable the Projects to execute their proposed goals. Characterizing the human immune response to YFV will accelerate the development of molecular predictors of immunity in humans, and optimize vaccination strategies for infectious disease.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-KS-I)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
United States
Zip Code
Hohensinner, Philipp J; Goronzy, Jörg J; Weyand, Cornelia M (2014) Targets of immune regeneration in rheumatoid arthritis. Mayo Clin Proc 89:563-75
Suthar, Mehul S; Pulendran, Bali (2014) Systems analysis of West Nile virus infection. Curr Opin Virol 6:70-5
Pulendran, Bali (2014) Systems vaccinology: probing humanity's diverse immune systems with vaccines. Proc Natl Acad Sci U S A 111:12300-6
Janssens, Sophie; Pulendran, Bali; Lambrecht, Bart N (2014) Emerging functions of the unfolded protein response in immunity. Nat Immunol 15:910-9
Kwissa, Marcin; Nakaya, Helder I; Onlamoon, Nattawat et al. (2014) Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation. Cell Host Microbe 16:115-27
Weyand, Cornelia M; Yang, Zhen; Goronzy, Jorg J (2014) T-cell aging in rheumatoid arthritis. Curr Opin Rheumatol 26:93-100
Yang, Rendong; Bai, Yun; Qin, Zhaohui et al. (2014) EgoNet: identification of human disease ego-network modules. BMC Genomics 15:314
Burke, Rachel M; Smith, Emily R; Dahl, Rebecca Moritz et al. (2014) The economic burden of pediatric gastroenteritis to Bolivian families: a cross-sectional study of correlates of catastrophic cost and overall cost burden. BMC Public Health 14:642
Chiu, Christopher; McCausland, Megan; Sidney, John et al. (2014) Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV. PLoS Pathog 10:e1004008
Jagger, Ann; Shimojima, Yasuhiro; Goronzy, Jorg J et al. (2014) Regulatory T cells and the immune aging process: a mini-review. Gerontology 60:130-7

Showing the most recent 10 out of 127 publications