The Administrative Core E will be supervised by the Program Director (PD) Dr. Daniel Salomon and the Co-Director, Mr. Tony Mondala along with administrative assistance from Ms. Cathy Luna. It will be located at The Scripps Research Institute in the Laboratory of Functional Genomics, Department of Molecular and Experimental Medicine. Since 2004, this Core has successfully supported the Transplant Genomics Collaborative Group (TGCG), the name we gave to the scientific and clinical collaborators that were brought together in the original application to pursue the objectives of this U19 Program Project grant: """"""""Genomics for Kidney Transplantation"""""""" (U19 AI063603-06;Dr. Salomon). In this competitive renewal. Administrative Core E has been evolved to address the new challenges including three major new collaborations. First, Clinical Core A is now centered at Northwestern University and directed by Dr. Michael Abecassis. This was a logical development to optimize the new Program's interactions with our CTOT grant (U01 AI084146-01) that was specifically developed to prospectively validate the genomic biomarker signatures developed by the TGCG in the last grant period. Second, we have added a new collaboration with the University of British Colombia/PROOF Centre directed by Dr. Bruce McManus (Project #4) that brings us new expertise in plasma proteomics, heart transplantation and a huge archive of clinical samples and genomic data generated by their own efforts for transplant biomarker discovery in the last 5 years. Third, we have brought in a novel technology platform, multi-parameter flow cytometry genomics directed at IncellDX by Dr. Bruce Patterson (Core B). In addition, as we moved the Clinical Core A from Scripps to Northwestern, we moved the sample receiving, processing and archiving into this new Administrative Core E and it will continue to be directed by Mr. Mondala and team. Finally, the new Program period will involve close coordination with both CTOT, the Genomics of Transplantation Cooperative Steering Committee (currently chaired by the Program Director) and the new data and statistical coordinating center managed by Rho Federal Systems.

Public Health Relevance

This new Program involves 4 scientific Projects, each with very different scientific expertise, and 5 Cores, comprising a total of 5 academic institutions, 1 company, 2 major NIH collaborative research consortia and Rho Federal Systems. There are multiple databases involved and harmonization of efforts in Canada and the U.S. involving funding streams from both. These are the tasks facing Administrative Core E and the team assembled has already demonstrated their ability to successfully manage this level of complexity.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Scripps Research Institute
La Jolla
United States
Zip Code
Leventhal, J R; Mathew, J M; Salomon, D R et al. (2016) Nonchimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers. Am J Transplant 16:221-34
LaMere, S A; Thompson, R C; Komori, H K et al. (2016) Promoter H3K4 methylation dynamically reinforces activation-induced pathways in human CD4 T cells. Genes Immun 17:283-97
Modena, B D; Milam, R; Harrison, F et al. (2016) Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies. Am J Transplant :
Savaryn, John P; Toby, Timothy K; Catherman, Adam D et al. (2016) Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection. Proteomics 16:2048-58
Weinsheimer, Shantel; Bendjilali, Nasrine; Nelson, Jeffrey et al. (2016) Genome-wide association study of sporadic brain arteriovenous malformations. J Neurol Neurosurg Psychiatry 87:916-23
Kurian, S M; Fouraschen, S M G; Langfelder, P et al. (2015) Genomic profiles and predictors of early allograft dysfunction after human liver transplantation. Am J Transplant 15:1605-14
Norden-Krichmar, Trina M; Gizer, Ian R; Phillips, Evelyn et al. (2015) Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. Twin Res Hum Genet 18:727-37
Magdeldin, Sameh; Blaser, Rachel E; Yamamoto, Tadashi et al. (2015) Behavioral and proteomic analysis of stress response in zebrafish (Danio rerio). J Proteome Res 14:943-52
Komori, H Kiyomi; Hart, Traver; LaMere, Sarah A et al. (2015) Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation. J Immunol 194:1565-79
Routh, Andrew; Head, Steven R; Ordoukhanian, Phillip et al. (2015) ClickSeq: Fragmentation-Free Next-Generation Sequencing via Click Ligation of Adaptors to Stochastically Terminated 3'-Azido cDNAs. J Mol Biol 427:2610-6

Showing the most recent 10 out of 66 publications