Successful collaboration between the multiple sites for this Hepatitis C Center project will require dedicated administrative efforts to include: 1) facilitating communication and data sharing between the three project sites and the related personnel and Pis, 2) coordination of schedules for teleconferences and travel, 3) heavy email traffic and phone contact in regards to manuscript preparations, travel, sample transport etc., and 4) management and reporting of all project site budgets and related subcontracts.

Public Health Relevance

Successful collaborafive efforts of any size are greatly enhanced when administrative professional personnel effort is dedicated to the organization and execution of all related administrative duites.

National Institute of Health (NIH)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1)
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University of Colorado Denver
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Giugliano, Silvia; Kriss, Michael; Golden-Mason, Lucy et al. (2015) Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology 148:392-402.e13
Lee, Hai-Chon; Narayanan, Sowmya; Park, Sung-Jae et al. (2014) Transcriptional regulation of IFN-? genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-?B complex. J Biol Chem 289:5310-9
Stone, Amy E L; Mitchell, Angela; Brownell, Jessica et al. (2014) Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression. PLoS One 9:e95627
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Brownell, Jessica; Bruckner, Jacob; Wagoner, Jessica et al. (2014) Direct, interferon-independent activation of the CXCL10 promoter by NF-*B and interferon regulatory factor 3 during hepatitis C virus infection. J Virol 88:1582-90
Lee, Hai-Chon; Sung, Sung-Sang J; Krueger, Peter D et al. (2013) Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes. Hepatology 57:1314-24
Golden-Mason, Lucy; Rosen, Hugo R (2013) Natural killer cells: multifaceted players with key roles in hepatitis C immunity. Immunol Rev 255:68-81
Polyak, Stephen J; Ferenci, Peter; Pawlotsky, Jean-Michel (2013) Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection. Hepatology 57:1262-71
Esser-Nobis, Katharina; Romero-Brey, Ines; Ganten, Tom M et al. (2013) Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B. Hepatology 57:953-63
Brownell, Jessica; Wagoner, Jessica; Lovelace, Erica S et al. (2013) Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes. J Hepatol 59:701-8

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