Successful collaboration between the multiple sites for this Hepatitis C Center project will require dedicated administrative efforts to include: 1) facilitating communication and data sharing between the three project sites and the related personnel and Pis, 2) coordination of schedules for teleconferences and travel, 3) heavy email traffic and phone contact in regards to manuscript preparations, travel, sample transport etc., and 4) management and reporting of all project site budgets and related subcontracts.

Public Health Relevance

Successful collaborafive efforts of any size are greatly enhanced when administrative professional personnel effort is dedicated to the organization and execution of all related administrative duites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI066328-10
Application #
8712328
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
City
Aurora
State
CO
Country
United States
Zip Code
80045
Narayanan, Sowmya; Surette, Fionna A; Hahn, Young S (2016) The Immune Landscape in Nonalcoholic Steatohepatitis. Immune Netw 16:147-58
Goh, Celeste C; Roggerson, Krystal M; Lee, Hai-Chon et al. (2016) Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1. J Immunol 196:2283-92
Lim, Sung In; Hahn, Young S; Kwon, Inchan (2015) Site-specific albumination of a therapeutic protein with multi-subunit to prolong activity in vivo. J Control Release 207:93-100
Giugliano, Silvia; Kriss, Michael; Golden-Mason, Lucy et al. (2015) Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology 148:392-402.e13
Labonte, Adam C; Tosello-Trampont, Annie-Carole; Hahn, Young S (2014) The role of macrophage polarization in infectious and inflammatory diseases. Mol Cells 37:275-85
Brownell, Jessica; Bruckner, Jacob; Wagoner, Jessica et al. (2014) Direct, interferon-independent activation of the CXCL10 promoter by NF-*B and interferon regulatory factor 3 during hepatitis C virus infection. J Virol 88:1582-90
Golden-Mason, Lucy; Hahn, Young S; Strong, Michael et al. (2014) Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection. PLoS One 9:e103219
Stone, Amy E L; Mitchell, Angela; Brownell, Jessica et al. (2014) Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression. PLoS One 9:e95627
Lee, Hai-Chon; Narayanan, Sowmya; Park, Sung-Jae et al. (2014) Transcriptional regulation of IFN-λ genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex. J Biol Chem 289:5310-9
Golden-Mason, Lucy; Rosen, Hugo R (2013) Natural killer cells: multifaceted players with key roles in hepatitis C immunity. Immunol Rev 255:68-81

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