The identification of acute HCV infection has been a major challenge throughout the years as its natural course is usually silent and asymptomatic. Collaborative efforts are being made throughout the worid to recognize new cases as they offer relevant information on viral and host interactions. This continued project has already identified 77 cases of acute HCV infection;most of which were symptomatic (80%), and with risk factors being mainly nosocomial in medical settings followed by sexual transmission. Spontaneous clearance was documented in 54%. and most cases were due to a single exposure as there were no reports of intravenous drug use. Even though patients were referred to hepatitis treatment centers as eariy as 3 months, a number of patients were not treated during the acute phase, and we were, surprisingly able to observe delayed spontaneous clearance in a few. Subjects adhered highly to the study and results have been obtained through a follow-up of pafients during a course of almost 9 years, with a high yield of sequenfial and serial bank specimens. This study will not only help identify HCV in the eariy phase of infecfion but also offer confinued long fime serial samples for further studies on immune pathogenesis for future development of successful immunotherapeutic intervenfions and vaccines.

Public Health Relevance

This core will provide long term follow-up samples critical for science projects to help understand the immune pathogenesis of HCV infection which will further assist in the identification of novel antiviral agents and development of efficacious vaccines.

National Institute of Health (NIH)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts General Hospital
United States
Zip Code
Zignego, A L; Wojcik, G L; Cacoub, P et al. (2014) Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis. Genes Immun 15:500-5
Nitschke, Katja; Barriga, Alejandro; Schmidt, Julia et al. (2014) HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope. J Hepatol 60:22-9
Kroy, Daniela C; Ciuffreda, Donatella; Cooperrider, Jennifer H et al. (2014) Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology 146:550-61
Wojcik, Genevieve; Latanich, Rachel; Mosbruger, Tim et al. (2014) Variants in HAVCR1 gene region contribute to hepatitis C persistence in African Americans. J Infect Dis 209:355-9
Cosgrove, Cormac; Berger, Christoph T; Kroy, Daniela C et al. (2014) Chronic HCV infection affects the NK cell phenotype in the blood more than in the liver. PLoS One 9:e105950
Grebely, Jason; Page, Kimberly; Sacks-Davis, Rachel et al. (2014) The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. Hepatology 59:109-20
Kim, Arthur Y; Onofrey, Shauna; Church, Daniel R (2013) An epidemiologic update on hepatitis C infection in persons living with or at risk of HIV infection. J Infect Dis 207 Suppl 1:S1-6
Ashraf, Shirin; Nitschke, Katja; Warshow, Usama M et al. (2013) Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection. Hepatology 58:881-9
Kim, Arthur Y; Nagami, Ellen H; Birch, Christopher E et al. (2013) A simple strategy to identify acute hepatitis C virus infection among newly incarcerated injection drug users. Hepatology 57:944-52
Linas, Benjamin P; Wong, Angela Y; Schackman, Bruce R et al. (2012) Cost-effective screening for acute hepatitis C virus infection in HIV-infected men who have sex with men. Clin Infect Dis 55:279-90

Showing the most recent 10 out of 30 publications