Abstract

The Proteomics Core supports research on Medical Countermeasures Against Radiation at UCLA by providing state-of-the-art mass spectrometry and expertise for the characterization of proteins and their post-translational modifications such as phosphorylation, and profiling changes in protein expression. The Core, centrally located for UCLA researchers in the Molecular Sciences Building, houses a wide range of equipment for protein separation, mass spectrometry-based protein characterization, and software to facilitate protein identification. Both top-down and bottom-up proteomic approaches will be applied to develop a multi-pronged approach to assemble the most complete picture of the effects of radiation exposure and their effects on protein structure.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI067769-01
Application #
7055618
Study Section
Special Emphasis Panel (ZCA1-SRRB-E (O1))
Project Start
2005-09-01
Project End
2010-07-31
Budget Start
2005-09-01
Budget End
2006-07-31
Support Year
1
Fiscal Year
2005
Total Cost
$290,791
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Woods, Kaley; Lee, Percy; Kaprealian, Tania et al. (2018) Cochlea-sparing acoustic neuroma treatment with 4? radiation therapy. Adv Radiat Oncol 3:100-107
Murray, David; Mirzayans, Razmik; McBride, William H (2018) Defenses against Pro-oxidant Forces - Maintenance of Cellular and Genomic Integrity and Longevity. Radiat Res 190:331-349
Sasine, Joshua P; Yeo, Kelly T; Chute, John P (2017) Concise Review: Paracrine Functions of Vascular Niche Cells in Regulating Hematopoietic Stem Cell Fate. Stem Cells Transl Med 6:482-489
Graham, Nicholas A; Minasyan, Aspram; Lomova, Anastasia et al. (2017) Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol 13:914
Kar, Upendra K; Simonian, Margaret; Whitelegge, Julian P (2017) Integral membrane proteins: bottom-up, top-down and structural proteomics. Expert Rev Proteomics 14:715-723
Duhachek-Muggy, Sara; Bhat, Kruttika; Vlashi, Erina et al. (2017) Growth Differentiation Factor 11 does not Mitigate the Lethal Effects of Total-Abdominal Irradiation. Radiat Res 188:469-475
Himburg, Heather A; Doan, Phuong L; Quarmyne, Mamle et al. (2017) Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. Nat Med 23:91-99
Micewicz, Ewa D; Kim, Kwanghee; Iwamoto, Keisuke S et al. (2017) 4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues. PLoS One 12:e0181577
Purbey, Prabhat K; Scumpia, Philip O; Kim, Peter J et al. (2017) Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation. Immunity 47:421-434.e3
McBride, William H; Ganapathy, Ekambaram; Lee, Mi-Heon et al. (2017) A perspective on the impact of radiation therapy on the immune rheostat. Br J Radiol 90:20170272

Showing the most recent 10 out of 93 publications