The purpose of this core is to create and implement administrative and leadership mechanisms that will foster effective interactions among the CMCR investigators and institutions to ensure a productive research effort. It is also responsible for overall organization, management, decision making, periodic evaluations, data sharing and involvement of institutional resources. The objectives of the Administrative Core are to: * Administer the budget;coordinate travel and purchasing. * Establish and organize an Internal Advisory Committee and an External Scientific Advisory Group. * Facilitate collaboration between the various Scientific Cores and Projects within the * Columbia CMCR. * Facilitate collaboration between this and other CMCRs. * Organize an annual retreat. * Coordinate patent applications. * Administer the Pilot program (see Core B for details). * Maintain the Consortium website

Public Health Relevance

A large scale radiological event could result in mass casualties from multiple types of radiation exposures, and there is thus a need for rapid, high-throughput biodosimetry to Identify those who most require treatment. The Administrative Core will provide support for research of high-throughput approaches to be useful for partial body, low dose rate, internal emitter, and neutron exposures, and also for potentially identifying individuals with particular sensitivities to radiation.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-KS-I)
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Columbia University (N.Y.)
New York
United States
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Sprung, Carl N; Ivashkevich, Alesia; Forrester, Helen B et al. (2015) Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects. Cancer Lett 356:72-81
Shuryak, Igor; Lubin, Jay H; Brenner, David J (2014) Potential for adult-based epidemiological studies to characterize overall cancer risks associated with a lifetime of CT scans. Radiat Res 181:584-91
Turner, Helen C; Sharma, P; Perrier, J R et al. (2014) The RABiT: high-throughput technology for assessing global DSB repair. Radiat Environ Biophys 53:265-72
Repin, Mikhail; Turner, Helen C; Garty, Guy et al. (2014) Next generation platforms for high-throughput biodosimetry. Radiat Prot Dosimetry 159:105-10
Laiakis, Evagelia C; Mak, Tytus D; Anizan, Sebastien et al. (2014) Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation. Radiat Res 181:350-61
Goudarzi, Maryam; Weber, Waylon; Mak, Tytus D et al. (2014) Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice. Radiat Res 181:54-64
Forrester, Helen B; Li, Jason; Leong, Trevor et al. (2014) Identification of a radiation sensitivity gene expression profile in primary fibroblasts derived from patients who developed radiotherapy-induced fibrosis. Radiother Oncol 111:186-93
Forrester, Helen B; Sprung, Carl N (2014) Intragenic controls utilizing radiation-induced alternative transcript regions improves gene expression biodosimetry. Radiat Res 181:314-23
Luo, Xiuquan; Suzuki, Masatoshi; Ghandhi, Shanaz A et al. (2014) ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PLoS One 9:e99983
Paul, Sunirmal; Ghandhi, Shanaz A; Weber, Waylon et al. (2014) Gene expression response of mice after a single dose of 137CS as an internal emitter. Radiat Res 182:380-9

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