The Fabrication Core consists of two currently existing facilities, the Design and Instrumentation Shop (DIS) at the Columbia Center for Radiological Research, and the Advanced Robotics and Mechanisms Applications (ARMA) Laboratory at the Columbia Department of Mechanical Engineering. Both these facilities have been central to the current CMCR developments to date. Both the DIS and ARMA provide services to the three Projects either directly or, frequently, through the Irradiation Core. We expect that the Fabrication Core will use approximately 50% of its resources for Project 1, 15% of its resources for Project 2, 25% of its resources for Project 3, and 10% of its resources for Pilot projects. For clarity, anticipated services provided by the Fabrication Core are categorized between those that are supporting developments with Projects, and those that are customizing currently available irradiation facilities to provide specific relevance to CMCR homeland security scenarios. Examples include Fabrication of new modules for the RABIT: 1. RABIT module for protein repair kinetics (for Project 1) 2. RABIT module for rapid mBAND analysis (for Project 1) 3. RABIT module for serum harvesting (for Project 3) Customizing currently available irradiation facilities: 4. Precision shield for partial-body irradiations (for all Projects) 5. IND-like neutron irradiation setup (for all Projects) 6. Micro-RT organ conformal irradiator (for all Projects) 7. Mouse housing for low dose rate studies (for all Projects) As has happened extensively in the current 4+ years of the Columbia CMCR, we anticipate that the Fabrication Core will also provide support for new needs that arise as the CMCR research develops, and new Pilot Projects come on line.
A large scale radiological event could result in mass casualties from multiple types of radiation exposures, and there is thus a need for rapid, high-throughput biodosimetry to identify those who most require treatment. The Fabrication Core will provide facilities to support the extension of high-throughput approaches to be useful for partial body, low dose rate, internal emitter, and neutron exposures, and also for potentially identifying Individuals with particular sensitivities to radiation.
|Laiakis, Evagelia C; Pannkuk, Evan L; Diaz-Rubio, Maria Elena et al. (2016) Implications of genotypic differences in the generation of a urinary metabolomics radiation signature. Mutat Res 788:41-9|
|Bertucci, Antonella; Smilenov, Lubomir B; Turner, Helen C et al. (2016) In vitro RABiT measurement of dose rate effects on radiation induction of micronuclei in human peripheral blood lymphocytes. Radiat Environ Biophys 55:53-9|
|Bian, Dakai; Tsui, Jason C; Repin, Mikhail et al. (2016) Liquid Handling Optimization in High-Throughput Biodosimetry Tool. J Med Device 10:0410071-4100710|
|Chen, Zhidan; Coy, Stephen L; Pannkuk, Evan L et al. (2016) Rapid and High-Throughput Detection and Quantitation of Radiation Biomarkers in Human and Nonhuman Primates by Differential Mobility Spectrometry-Mass Spectrometry. J Am Soc Mass Spectrom 27:1626-36|
|Edmondson, David A; Karski, Erin E; Kohlgruber, Ayano et al. (2016) Transcript Analysis for Internal Biodosimetry Using Peripheral Blood from Neuroblastoma Patients Treated with (131)I-mIBG, a Targeted Radionuclide. Radiat Res 186:235-44|
|Lacombe, Jerome; Phillips, Shanna Leslie; Zenhausern, Frederic (2016) Microfluidics as a new tool in radiation biology. Cancer Lett 371:292-300|
|Ghandhi, Shanaz A; Smilenov, Lubomir B; Elliston, Carl D et al. (2015) Radiation dose-rate effects on gene expression for human biodosimetry. BMC Med Genomics 8:22|
|Goldman, Devorah C; Alexeev, Vitali; Lash, Elizabeth et al. (2015) The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice. Radiat Res 183:338-44|
|Sprung, Carl N; Ivashkevich, Alesia; Forrester, Helen B et al. (2015) Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects. Cancer Lett 356:72-81|
|Mak, Tytus D; Tyburski, John B; Krausz, Kristopher W et al. (2015) Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat. Metabolomics 11:1082-1094|
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