The Fabrication Core consists of two currently existing facilities, the Design and Instrumentation Shop (DIS) at the Columbia Center for Radiological Research, and the Advanced Robotics and Mechanisms Applications (ARMA) Laboratory at the Columbia Department of Mechanical Engineering. Both these facilities have been central to the current CMCR developments to date. Both the DIS and ARMA provide services to the three Projects either directly or, frequently, through the Irradiation Core. We expect that the Fabrication Core will use approximately 50% of its resources for Project 1, 15% of its resources for Project 2, 25% of its resources for Project 3, and 10% of its resources for Pilot projects. For clarity, anticipated services provided by the Fabrication Core are categorized between those that are supporting developments with Projects, and those that are customizing currently available irradiation facilities to provide specific relevance to CMCR homeland security scenarios. Examples include Fabrication of new modules for the RABIT: 1. RABIT module for protein repair kinetics (for Project 1) 2. RABIT module for rapid mBAND analysis (for Project 1) 3. RABIT module for serum harvesting (for Project 3) Customizing currently available irradiation facilities: 4. Precision shield for partial-body irradiations (for all Projects) 5. IND-like neutron irradiation setup (for all Projects) 6. Micro-RT organ conformal irradiator (for all Projects) 7. Mouse housing for low dose rate studies (for all Projects) As has happened extensively in the current 4+ years of the Columbia CMCR, we anticipate that the Fabrication Core will also provide support for new needs that arise as the CMCR research develops, and new Pilot Projects come on line.
A large scale radiological event could result in mass casualties from multiple types of radiation exposures, and there is thus a need for rapid, high-throughput biodosimetry to identify those who most require treatment. The Fabrication Core will provide facilities to support the extension of high-throughput approaches to be useful for partial body, low dose rate, internal emitter, and neutron exposures, and also for potentially identifying Individuals with particular sensitivities to radiation.
|Sprung, Carl N; Ivashkevich, Alesia; Forrester, Helen B et al. (2015) Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects. Cancer Lett 356:72-81|
|Shuryak, Igor; Lubin, Jay H; Brenner, David J (2014) Potential for adult-based epidemiological studies to characterize overall cancer risks associated with a lifetime of CT scans. Radiat Res 181:584-91|
|Turner, Helen C; Sharma, P; Perrier, J R et al. (2014) The RABiT: high-throughput technology for assessing global DSB repair. Radiat Environ Biophys 53:265-72|
|Repin, Mikhail; Turner, Helen C; Garty, Guy et al. (2014) Next generation platforms for high-throughput biodosimetry. Radiat Prot Dosimetry 159:105-10|
|Laiakis, Evagelia C; Mak, Tytus D; Anizan, Sebastien et al. (2014) Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation. Radiat Res 181:350-61|
|Goudarzi, Maryam; Weber, Waylon; Mak, Tytus D et al. (2014) Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice. Radiat Res 181:54-64|
|Forrester, Helen B; Li, Jason; Leong, Trevor et al. (2014) Identification of a radiation sensitivity gene expression profile in primary fibroblasts derived from patients who developed radiotherapy-induced fibrosis. Radiother Oncol 111:186-93|
|Forrester, Helen B; Sprung, Carl N (2014) Intragenic controls utilizing radiation-induced alternative transcript regions improves gene expression biodosimetry. Radiat Res 181:314-23|
|Luo, Xiuquan; Suzuki, Masatoshi; Ghandhi, Shanaz A et al. (2014) ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PLoS One 9:e99983|
|Paul, Sunirmal; Ghandhi, Shanaz A; Weber, Waylon et al. (2014) Gene expression response of mice after a single dose of 137CS as an internal emitter. Radiat Res 182:380-9|
Showing the most recent 10 out of 85 publications