SPECIFIC AIMS The aims of Dosimetry Core will remain the same. The Dosimetry Core will be comprised of three subgroups within the Duke Radiation Dosimetry Laboratory (DRDL) providing the following services: (a) small animal dosimetry service, (b) computational dosimetry service, and (c) neutron dosimetry service. The RadCCORE Dosimetry Core has been providing investigators with high quality, state-of-the-art dosimetry support. The Core has been instrumental in developing new dose calibration techniques and making them available to RadCCORE Investigators. Administrative oversight for the Core will institute a charge-back mechanism to remain revenue neutral. 1. To ensure that radiation dosimetry consultation and health physics support are available to all RadCCORE members. 2. To ensure that the results obtained in one institution with a particular type of radiation are reproducible, transportable and easily understood to those of another institution. 3. To provide annual dose calibrations across the different institutions. 4. To provide neutron dosimetry at Duke Triangle Universities Nuclear Laboratory. 5. To provide computational dosimetry support in small animal dosimetry (Monte Carlo method). 6. To ensure timely incorporation of new state-of-the-art dosimetry technology to all RadCCORE members.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI067798-09
Application #
8508660
Study Section
Special Emphasis Panel (ZAI1-KS-I)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
9
Fiscal Year
2013
Total Cost
$41,534
Indirect Cost
$5,613
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Batinic-Haberle, Ines; Tovmasyan, Artak; Roberts, Emily R H et al. (2014) SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal 20:2372-415
Spitz, Douglas R; Hauer-Jensen, Martin (2014) Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine. Antioxid Redox Signal 20:1407-9
Himburg, Heather A; Yan, Xiao; Doan, Phuong L et al. (2014) Pleiotrophin mediates hematopoietic regeneration via activation of RAS. J Clin Invest 124:4753-8
Johnson, Jason N; Hornik, Christoph P; Li, Jennifer S et al. (2014) Cumulative radiation exposure and cancer risk estimation in children with heart disease. Circulation 130:161-7
Cheema, Amrita K; Pathak, Rupak; Zandkarimi, Fereshteh et al. (2014) Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation. J Proteome Res 13:3065-74
Lee, Chang-Lung; Lento, William E; Castle, Katherine D et al. (2014) Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice. Radiat Res 181:445-51
Hauer-Jensen, Martin (2014) Toward development of interleukin-11 as a medical countermeasure for use in radiological/nuclear emergencies. Dig Dis Sci 59:1349-51
Tovmasyan, Artak; Carballal, Sebastian; Ghazaryan, Robert et al. (2014) Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents. Inorg Chem 53:11467-83
Gauter-Fleckenstein, Benjamin; Reboucas, Julio S; Fleckenstein, Katharina et al. (2014) Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+). Redox Biol 2:400-10
Stanton, Ian N; Belley, Matthew D; Nguyen, Giao et al. (2014) Europium- and lithium-doped yttrium oxide nanocrystals that provide a linear emissive response with X-ray radiation exposure. Nanoscale 6:5284-8

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