The overall goal of the Biostatistics Core (Core B) is to promote scientific rigor in the conduct of RadCCORE research and to ensure the integrity of results. To this end, Core B will offer state-of-the-art biostatistics and bioinformatics support to RadCCORE projects and cores. This includes assistance in the statistical design, analysis and interpretation of data obtained from clinical, pre-clinical and laboratory studies, as well as molecular data obtained from genomic experiments and cell assays. Core B will also provide ongoing consulting and educational services to all RadCCORE investigators. Core B will use existing computing infrastructure resources as an efficient means to support RadCCORE research. It will also strive to take advantage of the vast amount of technical expertise in biostatistics, bioinformatics and information sciences within Duke University.

Public Health Relevance

Biostatistics plays an important role in biomedical research. Collaboration with biostatisticians has resulted in studies with clearly defined objectives, study designs well suited to address the questions being asked, and accurate and appropriate analyses. The Biostatistics Core (Core B) will provide the necessary biostatistics expertise and computational infrastructure in support of RadCCORE research.

Agency
National Institute of Health (NIH)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI067798-10
Application #
8704857
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
City
Durham
State
NC
Country
United States
Zip Code
27705
Batinic-Haberle, Ines; Tovmasyan, Artak; Roberts, Emily R H et al. (2014) SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal 20:2372-415
Spitz, Douglas R; Hauer-Jensen, Martin (2014) Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine. Antioxid Redox Signal 20:1407-9
Himburg, Heather A; Yan, Xiao; Doan, Phuong L et al. (2014) Pleiotrophin mediates hematopoietic regeneration via activation of RAS. J Clin Invest 124:4753-8
Johnson, Jason N; Hornik, Christoph P; Li, Jennifer S et al. (2014) Cumulative radiation exposure and cancer risk estimation in children with heart disease. Circulation 130:161-7
Cheema, Amrita K; Pathak, Rupak; Zandkarimi, Fereshteh et al. (2014) Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation. J Proteome Res 13:3065-74
Lee, Chang-Lung; Lento, William E; Castle, Katherine D et al. (2014) Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice. Radiat Res 181:445-51
Hauer-Jensen, Martin (2014) Toward development of interleukin-11 as a medical countermeasure for use in radiological/nuclear emergencies. Dig Dis Sci 59:1349-51
Tovmasyan, Artak; Carballal, Sebastian; Ghazaryan, Robert et al. (2014) Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents. Inorg Chem 53:11467-83
Gauter-Fleckenstein, Benjamin; Reboucas, Julio S; Fleckenstein, Katharina et al. (2014) Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+). Redox Biol 2:400-10
Stanton, Ian N; Belley, Matthew D; Nguyen, Giao et al. (2014) Europium- and lithium-doped yttrium oxide nanocrystals that provide a linear emissive response with X-ray radiation exposure. Nanoscale 6:5284-8

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