SPECIFIC AIMS The aims of Dosimetry Core will remain the same. The Dosimetry Core will be comprised of three subgroups within the Duke Radiation Dosimetry Laboratory (DRDL) providing the following services: (a) small animal dosimetry service, (b) computational dosimetry service, and (c) neutron dosimetry service. The RadCCORE Dosimetry Core has been providing investigators with high quality, state-of-the-art dosimetry support. The Core has been instrumental in developing new dose calibration techniques and making them available to RadCCORE Investigators. Administrative oversight for the Core will institute a charge-back mechanism to remain revenue neutral. 1. To ensure that radiation dosimetry consultation and health physics support are available to all RadCCORE members. 2. To ensure that the results obtained in one institution with a particular type of radiation are reproducible, transportable and easily understood to those of another institution. 3. To provide annual dose calibrations across the different institutions. 4. To provide neutron dosimetry at Duke Triangle Universities Nuclear Laboratory. 5. To provide computational dosimetry support in small animal dosimetry (Monte Carlo method). 6. To ensure timely incorporation of new state-of-the-art dosimetry technology to all RadCCORE members.

Agency
National Institute of Health (NIH)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI067798-10
Application #
8704861
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
City
Durham
State
NC
Country
United States
Zip Code
27705
Mont, Stacey; Davies, Sean S; Roberts Second, L Jackson et al. (2016) Accumulation of isolevuglandin-modified protein in normal and fibrotic lung. Sci Rep 6:24919
Hanbury, David B; Peiffer, Ann M; Dugan, Greg et al. (2016) Long-Term Cognitive Functioning in Single-Dose Total-Body Gamma-Irradiated Rhesus Monkeys ( Macaca mulatta ). Radiat Res 186:447-454
Koechlein, Claire S; Harris, Jeffrey R; Lee, Timothy K et al. (2016) High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo. Nat Commun 7:12169
DeBo, Ryne J; Lees, Cynthia J; Dugan, Greg O et al. (2016) Late Effects of Total-Body Gamma Irradiation on Cardiac Structure and Function in Male Rhesus Macaques. Radiat Res 186:55-64
Batinic-Haberle, Ines; Tovmasyan, Artak; Spasojevic, Ivan (2015) An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways. Redox Biol 5:43-65
Gomez, John C; Yamada, Mitsuhiro; Martin, Jessica R et al. (2015) Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia. Am J Respir Cell Mol Biol 52:349-64
Hanbury, David B; Robbins, Mike E; Bourland, J Daniel et al. (2015) Pathology of fractionated whole-brain irradiation in rhesus monkeys ( Macaca mulatta ). Radiat Res 183:367-74
Krauss, Jennifer L; Zeng, Rong; Hickman-Brecks, Cynthia L et al. (2015) NLRP12 provides a critical checkpoint for osteoclast differentiation. Proc Natl Acad Sci U S A 112:10455-60
Johnson, Jason N; Hornik, Christoph P; Li, Jennifer S et al. (2015) Response to letters regarding article, "Cumulative radiation exposure and cancer risk estimation in children with heart disease". Circulation 131:e419-20
Cheong, Woo-Chang; Kang, Hye-Ri; Yoon, Hyunyee et al. (2015) Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome. PLoS One 10:e0126456

Showing the most recent 10 out of 178 publications