for Coordinating Center Core (CCC) The UPCI-CMCR-CCC will provide three critical services to NIAID and the other components of the 5 ? 7 CMCR Programs. The CCC will cooperatively develop a program for archiving and distributing data from 5 ? 7 CMCR sites and will maintain electronic data storage and develop security passcodes and validations for retrieval of data. The CCC will develop a program for timely submission of data and data analysis at NIAID/NIH and maintain rapid availability of electronic exchange of records to CMCR Programs as well as the general scientific community. The CCC will coordinate administrative activities for the scientists organizing national meetings, coordinating conference calls, establishing three levels of firewalls to distribute information at levels of CMCR Centers locally, CMCR Programmatic Centers for all 5 ? 7 programs, and to the general scientific community. Finally, the CCC will administer funds for the development of web-based training programs in four key areas: 1) Principles of Radiobiology, 2) Use of assays, methods, reagents, and animal models, 3) Technologies to study radiobiology and develop new product regulatory process, and, finally, 4) A course on triaging radiation casualties in the event of a radiation terrorist event.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI068021-11
Application #
8940566
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
11
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Anthonymuthu, Tamil S; Kenny, Elizabeth M; Amoscato, Andrew A et al. (2017) Global assessment of oxidized free fatty acids in brain reveals an enzymatic predominance to oxidative signaling after trauma. Biochim Biophys Acta 1863:2601-2613
Tong, J; Tan, S; Zou, F et al. (2017) FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. Oncogene 36:787-796
Brand, Rhonda M; Epperly, Michael W; Stottlemyer, J Mark et al. (2017) A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage. J Invest Dermatol 137:576-586
Kagan, Valerian E; Bay?r, Hülya; Tyurina, Yulia Y et al. (2017) Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids. Biochem Biophys Res Commun 482:482-490
Tong, Jingshan; Wang, Peng; Tan, Shuai et al. (2017) Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res 77:2512-2521
Maguire, John J; Tyurina, Yulia Y; Mohammadyani, Dariush et al. (2017) Known unknowns of cardiolipin signaling: The best is yet to come. Biochim Biophys Acta 1862:8-24
Tyurina, Yulia Y; Lou, Wenjia; Qu, Feng et al. (2017) Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells. ACS Chem Biol 12:265-281
Kagan, Valerian E; Mao, Gaowei; Qu, Feng et al. (2017) Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol 13:81-90
Wenzel, Sally E; Tyurina, Yulia Y; Zhao, Jinming et al. (2017) PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell 171:628-641.e26
Liu, Bing; Oltvai, Zoltán N; Bay?r, Hülya et al. (2017) Quantitative assessment of cell fate decision between autophagy and apoptosis. Sci Rep 7:17605

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