Abstract

The objectives of the Chemistry and Product Development Core are to provide sufficient quantities of the candidate microbicides to be investigated to each Core and Project to assure that the goals of the total Program are met efficiently. In addition, ImQuest Pharmaceuticals, as the Corporate Partner of the project, will provide needed assistance with studies being performed to assure that product development initiatives are met utilizing the cutting edge scientific methods and technology that will be produced by the consortium. ImQuest Pharmaceuticals will have confidentiality agreements and Memorandum of Understanding between the company and all team members and Institutions to facilitate successful completion of the research goals and the initiation of IND-directed studies on single and combination products which are coitally independent and long lasting microbicide alternatives for vaginal and rectal use. ImQuest Pharmaceuticals will provide IND-directed scientific and regulatory capacity to develop these products through their own resources or through emerging relationships or discussions with the NIH and other Foundations such as International Partnership for Microbicides (IPM).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI077289-05
Application #
8380874
Study Section
Special Emphasis Panel (ZAI1-CCH-A)
Project Start
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
5
Fiscal Year
2012
Total Cost
$157,376
Indirect Cost
$10,385

  Institution

Name
Imquest Biosciences
Department
Type
DUNS #
146051664
City
Frederick
State
MD
Country
United States
Zip Code
21704

  Publications

Gao, Yajing; Katz, David F (2017) Multicompartmental Pharmacokinetic Model of Tenofovir Delivery to the Rectal Mucosa by an Enema. PLoS One 12:e0167696
Funke, Claire; MacMillan, Kelsey; Ham, Anthony et al. (2016) Coupled gel spreading and diffusive transport models describing microbicidal drug delivery. Chem Eng Sci 152:12-20
Gao, Y; Yuan, A; Chuchuen, O et al. (2015) Vaginal deployment and tenofovir delivery by microbicide gels. Drug Deliv Transl Res 5:279-94
Katz, David F; Yuan, Andrew; Gao, Yajing (2015) Vaginal drug distribution modeling. Adv Drug Deliv Rev 92:2-13
Morrow Guthrie, Kate; Vargas, Sara; Shaw, Julia G et al. (2015) The Promise of Intravaginal Rings for Prevention: User Perceptions of Biomechanical Properties and Implications for Prevention Product Development. PLoS One 10:e0145642
Rosen, Rochelle K; van den Berg, Jacob J; Vargas, Sara E et al. (2015) Meaning-making matters in product design: users' sensory perceptions and experience evaluations of long-acting vaginal gels and intravaginal rings. Contraception 92:596-601
Ugaonkar, Shweta R; Clark, Justin T; English, Lexie B et al. (2015) An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission. J Pharm Sci 104:3426-39
van den Berg, Jacob J; Rosen, Rochelle K; Bregman, Dana E et al. (2014) ""Set it and forget it"": women's perceptions and opinions of long-acting topical vaginal gels. AIDS Behav 18:862-70
Tolley, Elizabeth E; Morrow, Kathleen M; Owen, Derek H (2013) Designing a multipurpose technology for acceptability and adherence. Antiviral Res 100 Suppl:S54-9
Rastogi, Rachna; Teller, Ryan S; Mesquita, Pedro M M et al. (2013) Osmotic pump tablets for delivery of antiretrovirals to the vaginal mucosa. Antiviral Res 100:255-8

Showing the most recent 10 out of 25 publications