Abstract

The purpose of Core B is to provide a Program for Pilot/Feasibility Studies in association with the HCV Persistence Study Group (HPSG). Core B will be located in Dr. Chung's laboratory/office complex at the Liver Center/Gastrointestinal Division of Massachusetts General Hospital. The main goals of Core B are to administer and oversee the Pilot/Feasibility Studies Program of the HPSG. The specific tasks of Core B will be to: (a) solicit applications for the PES program annually;(b) provide a mechanism for scientific peer review of the PES applications;(c) monitor research progress;and (d) to organize an annual scientific symposium (in conjunction with the annual visit of the U19 External Scientific Advisory Group) for PES awardees to present their research findings;In this regard. Core B will be closely intertwined with the operations of Core A (Administrative), as there will be substantive thematic overlap between the two cores. It is expected that one of the key benefits of Core B's activities will be to foster additional scientific interactions between members of the local scientific community and the PIs of the HPSG program.

Public Health Relevance

CORE B is an essential structure that will support pilot and feasibility projects that enhance and enrich the scope and quality ofthe science ofthe main Projects and Cores ofthe Hepatitis C Persistence Study Group, in so doing fostering new interactions with HPSG Pis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI082630-06
Application #
8726066
Study Section
Special Emphasis Panel (ZAI1-LAR-I (J1))
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
6
Fiscal Year
2014
Total Cost
$69,290
Indirect Cost
$19,290

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Stelekati, Erietta; Chen, Zeyu; Manne, Sasikanth et al. (2018) Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155. Cell Rep 23:2142-2156
Kurioka, Ayako; van Wilgenburg, Bonnie; Javan, Reza Rezaei et al. (2018) Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways. J Infect Dis 217:988-999
Qu, Chen; Zheng, Dandan; Li, Sai et al. (2018) Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis. Hepatology :
Yu, Wen-Han; Cosgrove, Cormac; Berger, Christoph T et al. (2018) ADCC-Mediated CD56DIM NK Cell Responses Are Associated with Early HBsAg Clearance in Acute HBV Infection. Pathog Immun 3:2-18
Johnson, John L; Georgakilas, Georgios; Petrovic, Jelena et al. (2018) Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells. Immunity 48:243-257.e10
Gordon, Claire L; Hutchings, Claire L; Highton, Andrew J et al. (2018) Memory inflation following adenoviral vaccination depends on IL-21. Vaccine 36:7011-7016
Carty, Shannon A; Gohil, Mercy; Banks, Lauren B et al. (2018) The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation. J Immunol 200:82-91
Gordon, Claire Louse; Lee, Lian Ni; Swadling, Leo et al. (2018) Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines. Cell Rep 23:768-782
Duan, Xiaoqiong; Li, Shilin; Holmes, Jacinta A et al. (2018) MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway. J Virol 92:
Bengsch, Bertram; Ohtani, Takuya; Khan, Omar et al. (2018) Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity 48:1029-1045.e5

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