The proposed University of Maryland, Baltimore (UMB) CCHI Administrative Core will be responsible for overall organization, management, decision-making, evaluation and supervising the entire range of CCHI activities to ensure highly productive research efforts. To that end the Core will focus on: 1.) facilitating communications amongst the Research Projects, Service and Pilot Cores, Opportunity Fund Management Core and Principal Investigator;2.) implementation of periodic evaluations;4.) allocating and reallocating resources to meet program goals;5.) tracking and prioritizing fiscal and other resources;and 6.) organizing presentations and publication of data. The goal of the Administrative Core is the successful implementation of UMB-CCHI goals and objectives so that the specific aims of each Project and Core may be accomplished. A key mission of this Core is to maintain a stable, flexible, yet centralized infrastructure to promote and harmonize the research conducted on human immunology. The Administrative Team brings with it breadth and depth of experience in managing large diverse grants including the current UMB-CCHI grant for the past 4 years. This same Team will work together to coordinate the activities of the CCHI Research Projects as well as the Service and Pilot Cores, and the Opportunity Fund Management Core that are meant to support and synergize the research.

Public Health Relevance

The UMB-CCHI Administrative Core Team will provide the infrastructure and leadership that will be central to the Center's success. This experienced team is prepared to manage, coordinate, and supervise the full range of Center activities with the primary goal of successful implementation of CCHI goals and objectives so that the specific aims of each research project may be accomplished.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI082655-06
Application #
8726151
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Salerno-Goncalves, R; Safavie, F; Fasano, A et al. (2016) Free and complexed-secretory immunoglobulin A triggers distinct intestinal epithelial cell responses. Clin Exp Immunol 185:338-47
Fresnay, Stephanie; McArthur, Monica A; Magder, Laurence et al. (2016) Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans. J Transl Med 14:62
Blohmke, Christoph J; Darton, Thomas C; Jones, Claire et al. (2016) Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever. J Exp Med 213:1061-77
Salerno-Goncalves, Rosangela; Fasano, Alessio; Sztein, Marcelo B (2016) Development of a Multicellular Three-dimensional Organotypic Model of the Human Intestinal Mucosa Grown Under Microgravity. J Vis Exp :
McArthur, Monica A; Fresnay, Stephanie; Magder, Laurence S et al. (2015) Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model. PLoS Pathog 11:e1004914
Trebicka, Estela; Shanmugam, Nanda Kumar N; Chen, Kejie et al. (2015) Intestinal Inflammation Leads to a Long-lasting Increase in Resistance to Systemic Salmonellosis that Requires Macrophages But Not B or T Lymphocytes at the Time of Pathogen Challenge. Inflamm Bowel Dis 21:2758-65
Wahid, R; Fresnay, S; Levine, M M et al. (2015) Immunization with Ty21a live oral typhoid vaccine elicits crossreactive multifunctional CD8+ T-cell responses against Salmonella enterica serovar Typhi, S. Paratyphi A, and S. Paratyphi B in humans. Mucosal Immunol 8:1349-59
Booth, Jayaum S; Salerno-Goncalves, Rosangela; Blanchard, Thomas G et al. (2015) Mucosal-Associated Invariant T Cells in the Human Gastric Mucosa and Blood: Role in Helicobacter pylori Infection. Front Immunol 6:466
Toapanta, Franklin R; Bernal, Paula J; Fresnay, Stephanie et al. (2015) Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease. PLoS Negl Trop Dis 9:e0003837
Sztein, Marcelo B; Salerno-Goncalves, Rosangela; McArthur, Monica A (2014) Complex adaptive immunity to enteric fevers in humans: lessons learned and the path forward. Front Immunol 5:516

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