The overall objective of the Clinical Core is to provide human specimens for the studies described in Research Projects 1-3. These specimens will supplement the existing extensive collection of unique banked specimens that are being used and accrued in the current CCHI. Note: the core will only obtain human specimens from subjects who are receiving the standard-of-care (e.g., vaccinated with the Ty21a typhoid vaccine because of travel to endemic areas or work in microbiology labs, or undergoing medically-indicated colonoscopies) and do not involve off-label interventions. The goals of this core will be achieved through the following specific aims.

Public Health Relevance

The availability of human specimens will be a crucial resource for the three Research Projects (RPI-3) and their goals to comprehensively study the local and systemic immune response to vaccination, evaluate the role of the gut microbiome, and measure the role of the micro-milieu in response to S. Typhi. The Clinical Core will support the interrelated, complementary, interactive goals of RPI-3.

National Institute of Health (NIH)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1)
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University of Maryland Baltimore
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