Abstract

The Pilot Project Core is proposed as an integral part of the CCHI to support research to generate preliminary data for the development and submission of future research applications for support from non- CCHI sources. A major purpose of this Core will be to enhance the UMB-CCHI research portfolio and the field of human immunology as it relates to defense against infectious disease. As such, the UMB-CCHI Pilot Project Core has the following Specific Aims:
Aim 1 : To enrich the UMB-CCHI research portfolio and incorporate new investigators and institutions into the field of human immunology for the purpose of generating preliminary data for the development and submission of future research applications in the area of human immunology.
Aim 2 : To solicit and review Pilot Project applications for two to three awards in the amount of $30,000 to $50,000 every two years.
Aim 3 : To support, monitor and integrate Pilot Projects into the UMB-CCHI research portfolio.
Aim 4 : To track the success of funded Pilot Projects as measured by publications, presentations, patents, and the ability to obtain subsequent funding.

Public Health Relevance

The Pilot Project Core is proposed as an integral part of the CCHI to support research to generate preliminary data for the development and submission of future research applications for support from non- CCHI sources. A major purpose of this Core will be to enhance the UMB-CCHI research portfolio and the field of human immunology as it relates to defense against infectious disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI082655-06
Application #
8726154
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Haney, Douglas J; Lock, Michael D; Gurwith, Marc et al. (2018) Lipopolysaccharide-specific memory B cell responses to an attenuated live cholera vaccine are associated with protection against Vibrio cholerae infection. Vaccine 36:2768-2773
Davis, Courtney L; Wahid, Rezwanul; Toapanta, Franklin R et al. (2018) A clinically parameterized mathematical model of Shigella immunity to inform vaccine design. PLoS One 13:e0189571
Toapanta, Franklin R; Bernal, Paula J; Kotloff, Karen L et al. (2018) T cell mediated immunity induced by the live-attenuated Shigella flexneri 2a vaccine candidate CVD 1208S in humans. J Transl Med 16:61
Zhang, Yan; Brady, Arthur; Jones, Cheron et al. (2018) Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi. MBio 9:
Senger, Stefania; Ingano, Laura; Freire, Rachel et al. (2018) Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC). Cell Mol Gastroenterol Hepatol 5:549-568
Sztein, Marcelo B (2018) Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell-Mediated Protective Immunity and Vaccination against Enteric Bacteria. Cold Spring Harb Perspect Biol 10:
Salerno-Gonçalves, Rosângela; Tettelin, Hervé; Lou, David et al. (2017) Use of a novel antigen expressing system to study the Salmonella enterica serovar Typhi protein recognition by T cells. PLoS Negl Trop Dis 11:e0005912
Booth, Jayaum S; Patil, Seema A; Ghazi, Leyla et al. (2017) Systemic and Terminal Ileum Mucosal Immunity Elicited by Oral Immunization With the Ty21a Typhoid Vaccine in Humans. Cell Mol Gastroenterol Hepatol 4:419-437
Fresnay, Stephanie; McArthur, Monica A; Magder, Laurence S et al. (2017) Importance ofSalmonellaTyphi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model. Front Immunol 8:208
Salerno-Goncalves, Rosângela; Luo, David; Fresnay, Stephanie et al. (2017) Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells. Front Immunol 8:398

Showing the most recent 10 out of 59 publications