The Administrative Core will support and facilitate the translational research that is described in the Yale Autoimmunity Center of Excellence. The following Aims are proposed for the Core:
Specific Aim 1 : To perform the administrative tasks for the Yale ACE. The Core will arrange the monthly meetings of the ACE and the meetings of the Executive Committee. The Core will also provide support to fulfill the local regulatory requirements for clinical trials, and where needed, animal protocols.
Specific Aim 2 : To facilitate interactions among all of the participating clincical investigators. The Core will provide the regulatory support needed for approval of clinical trials at sites off the Yale campus. Samples that are shared between sites will be managed by the Core.
Specific Aim 3 : To establish a recruitment "team" for clinical trials. A research coordinator will be supported by the Administrative Core. This individual will interact closely with the Yale Center for Clinical Investigation and use resources that are available from the CTSA to help with clinical studies.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-QV-I)
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Yale University
New Haven
United States
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Hedl, Matija; Zheng, Shasha; Abraham, Clara (2014) The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways. J Immunol 192:5924-32
Castiello, Maria Carmina; Bosticardo, Marita; Pala, Francesca et al. (2014) Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans. J Autoimmun 50:42-50
Hedl, Matija; Abraham, Clara (2014) A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1. Proc Natl Acad Sci U S A 111:13451-6
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Hedl, Matija; Lahiri, Amit; Ning, Kaida et al. (2014) Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele. Immunity 40:734-46
Ruddle, Nancy H (2014) Lymphatic vessels and tertiary lymphoid organs. J Clin Invest 124:953-9
Vudattu, Nalini K; Waldron-Lynch, Frank; Truman, Lucy A et al. (2014) Humanized mice as a model for aberrant responses in human T cell immunotherapy. J Immunol 193:587-96
Wu, Xingxin; Lahiri, Amit; Haines 3rd, G Kenneth et al. (2014) NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury. J Immunol 192:3409-18
Lahiri, Amit; Abraham, Clara (2014) Activation of pattern recognition receptors up-regulates metallothioneins, thereby increasing intracellular accumulation of zinc, autophagy, and bacterial clearance by macrophages. Gastroenterology 147:835-46
Sehgal, Kartik; Ragheb, Ragy; Fahmy, Tarek M et al. (2014) Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk. J Immunol 193:2297-305

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