The Administrative Core will provide management and leadership to the Oklahoma Autoimmunity Center of Excellence (Oklahoma ACE) allowing for expedited translation of basic science advances into clinical application in the diagnosis and treatment of systemic autoimmune disease. In support of this goal, the Administrative Core will serve as the centralized coordinating resource for the ACE. Based upon its previous success, the Oklahoma ACE will continue to host a weekly Autoimmunity Forum, bringing together the 14 basic scientists and 12 clinical investigators, representing a number of different clinical specialties and complementary research areas, who serve as part of the Oklahoma ACE, as well as their trainees and other interested parties. We will also continue to invite ACE investigators from the rest of the ACE network to help forge and facilitate inter-ACE collaborations^ To accomplish these goals, the Administrative Core will focus on the following Services: 1) provide central management for the Oklahoma ACE components and activities; 2) facilitate interactions of the Oklahoma ACE with the ACE Network and the NIH ACE Program;3) promote multidisciplinary approaches to research;and 4) promote data sharing strategies. The Core Leader will facilitate communication among the ACE community, ensure compliance with all NIH policies, and provide a foundation for scientific growth in translational and basic research. The Administrative Core Leader will oversee all administrative and personnel issues, work with ACE investigators to resolve issues, review project progress, and assist in grant applications and publications developed by ACE investigators. The Core Leader will attend ACE Steering Committee meetings and be the primary contact for the NIH ACE Program. The Core Leader and administrative staff will be responsible for preparing and submitting all annual progress reports and just-in-time and other information as needed to the NIH. Through the assistance ofthe OMRF grants accounting office, the Core Leader and administrative staff will also be responsible for managing the Oklahoma ACE budget. The Administrative Core services will optimize the use of funding and ensure that the Oklahoma ACE goals are met in a timely manner.

Public Health Relevance

The Oklahoma ACE is comprised of a multidisciplinary team of physician scientists and basic science investigators with the common goal of improving autoimmune disease patient care through expediting the translation of basic science findings into clinical applications. The Administrative Core will provide the, Oklahoma ACE with centralized leadership and management.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1)
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Oklahoma Medical Research Foundation
Oklahoma City
United States
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Munroe, Melissa E; Vista, Evan S; Merrill, Joan T et al. (2017) Pathways of impending disease flare in African-American systemic lupus erythematosus patients. J Autoimmun 78:70-78
Arriens, Cristina; Wren, Jonathan D; Munroe, Melissa E et al. (2017) Systemic lupus erythematosus biomarkers: the challenging quest. Rheumatology (Oxford) 56:i32-i45
Aberle, Teresa; Bourn, Rebecka L; Chen, Hua et al. (2017) Use of SLICC criteria in a large, diverse lupus registry enables SLE classification of a subset of ACR-designated subjects with incomplete lupus. Lupus Sci Med 4:e000176
Langefeld, Carl D; Ainsworth, Hannah C; Cunninghame Graham, Deborah S et al. (2017) Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun 8:16021
Munroe, Melissa E; Young, Kendra A; Kamen, Diane L et al. (2017) Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features. Arthritis Rheumatol 69:630-642
Glauzy, Salomé; Boccitto, Marco; Bannock, Jason M et al. (2017) Accumulation of Antigen-Driven Lymphoproliferations in Complement Receptor 2/CD21-/low B Cells From Patients With Sjögren's Syndrome. Arthritis Rheumatol :
Jog, Neelakshi R; James, Judith A (2017) Biomarkers in connective tissue diseases. J Allergy Clin Immunol 140:1473-1483
Merrill, Joan T; Immermann, Fred; Whitley, Maryann et al. (2017) The Biomarkers of Lupus Disease Study: A Bold Approach May Mitigate Interference of Background Immunosuppressants in Clinical Trials. Arthritis Rheumatol 69:1257-1266
Young, Kendra A; Munroe, Melissa E; Guthridge, Joel M et al. (2017) Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus. Ann Rheum Dis 76:153-158
Sandhya, Pulukool; Kurien, Biji Theyilamannil; Danda, Debashish et al. (2017) Update on Pathogenesis of Sjogren's Syndrome. Curr Rheumatol Rev 13:5-22

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