The proposed Autoimmunity Center of Excellence entitled, """"""""Novel Innate and Adaptive Immunity Pathways Lead to Human Systemic Autoimmunity"""""""" will utilize a multidisciplinary team of investigators to conduct important collaborative research on systemic lupus erythematosus (SLE) and other autoimmune diseases. To that end three projects (Principle, Pilot, and Collaborative) and two Cores (Administrative and Bioinformatics) are planned and an External Advisory Committee is proposed. Therefore, there is considerable need to coordinate and support the various activities of this Center. The role of the Administrative Core (Core A) is to provide scientific leadership, organizational structure, and staff support. As such, the responsibilities of the Administrative team include: 1. Promoting and facilitating interactions among all Center investigators, projects, cores (associated with the Center and other established cores at BIIR), and collaborators, including other ACE sites 2. Prioritize, allocate, and manage resources - including budgets and personnel 3. Facilitate sample acquisition and retrieval of clinical data from local clinics and other collaborators, including ACE sites 4. Fostering productive interactions between Center investigators and the Advisory Group, including arranging an annual Advisory Group Meeting that includes all principal investigators, outside consultants, and the entire Advisory Group, 5. Facilitate data sharing within BIIR and outside, especially with other ACE sites 6. Assisting and overseeing all regulatory issues, including preparation of all protocol submissions and annual renewals to the Institutional Review Board (IRB), as well as assisting with issues related to Intellectual Property. 7. Complete annual NIH progress reporting

Public Health Relevance

Three Projects, two Cores, and an annual Advisory Board Meeting are proposed for the ACE at BIIR. There is considerable need to coordinate and support the various activities - scientific, administrative, and clinical - of this Center. The Administrative Core will be responsible for the organization and seamless workings between all Investigators, clinicians, collaborators, and advisors to insure a successful ACE.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI082715-06
Application #
8732919
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2014-05-01
Project End
2019-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Baylor Research Institute
Department
Type
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75204
Cepika, Alma-Martina; Banchereau, Romain; Segura, Elodie et al. (2017) A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis. J Exp Med 214:3449-3466
Banchereau, Romain; Cepika, Alma-Martina; Banchereau, Jacques et al. (2017) Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics. Annu Rev Immunol 35:337-370
Schmitt, Nathalie; Liu, Yang; Bentebibel, Salah-Eddine et al. (2016) Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans. Cell Rep 16:1082-1095
Blanco, Patrick; Ueno, Hideki; Schmitt, Nathalie (2016) T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis. Eur J Immunol 46:281-90
Caielli, Simone; Athale, Shruti; Domic, Bojana et al. (2016) Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus. J Exp Med 213:697-713
Banchereau, Romain; Hong, Seunghee; Cantarel, Brandi et al. (2016) Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients. Cell 165:551-65
Turner, Jacob A; Bolen, Christopher R; Blankenship, Derek M (2015) Quantitative gene set analysis generalized for repeated measures, confounder adjustment, and continuous covariates. BMC Bioinformatics 16:272
Jacquemin, Clément; Schmitt, Nathalie; Contin-Bordes, Cécile et al. (2015) OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response. Immunity 42:1159-70
Schmitt, Nathalie (2015) Role of T Follicular Helper cells in Multiple Sclerosis. J Nat Sci 1:e139
Schmitt, Nathalie; Ueno, Hideki (2015) Regulation of human helper T cell subset differentiation by cytokines. Curr Opin Immunol 34:130-6

Showing the most recent 10 out of 37 publications