The Administrative Core (Core A) will provide the support mechanisms to each Project and Core within the Center to foster interaction both within the program and with the outside scientific community. This core will support bi-weekly interactions between the Projects and Cores, as well as communication software to allow daily face to face interactions, if necessary. This core will support a full time Program Coordinator (PC) who will provide administrative support to the program and will be responsible for coordinating and maintaining the continuity of the administrative work flow and communication. The PC will ensure that all administrative deadlines are met, and will have the responsibility for organizing and coordinating all the travel including, monthly program meetings, annual retreats and attendance of the project leaders to the annual NIAID meeting "Immune Mechanism of Virus Control". The project coordinator will report to the principal investigator (PI) on all administrative aspects of the program, and in conjunction with the PI, will prepare reports and budgetary materials, coordinate activity with the business office and manage correspondence with collaborators. The PC will also be involved in the preparation of reports, publications, etc., as well as the filing of any appropriate protocols or other documentation needed in connection with the research. Additional duties will be organizing the transfer of materials (mice, tissues, viruses) between laboratories and the sharing of reagents with the scientific community. The Core will also support a yearly retreat which will include attendance by members of the External Scientific Advisory Board for the Center, and select invited speakers to foster interaction with the viral immunology community as a whole. In summary, this Core is the glue that will hold the Center together, and allow the free and easy exchange of scientific discoveries between the Projects and Cores within the Center, and between the Center and the scientific community.

Public Health Relevance

This U19 should substantially contribute to understanding the immune mechanisms that control viral infections in natural hosts including those of humans. Thus, by helping the Program Project achieve its Aims, the work of the Administrative Core will indirectly contribute to the promotion of human health.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-BDP-I)
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Research Institute of Fox Chase Cancer Center
United States
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Davies, Michael L; Sei, Janet J; Siciliano, Nicholas A et al. (2014) MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2. J Virol 88:3557-67
Heipertz, Erica L; Davies, Michael L; Lin, Eugene et al. (2014) Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation. J Immunol 193:4169-77
Siciliano, Nicholas A; Hersperger, Adam R; Lacuanan, Aimee M et al. (2014) Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses. J Virol 88:10078-91
Hersperger, Adam R; Siciliano, Nicholas A; DeHaven, Brian C et al. (2014) Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection. J Virol 88:9472-5
Remakus, Sanda; Rubio, Daniel; Lev, Avital et al. (2013) Memory CD8? T cells can outsource IFN-? production but not cytolytic killing for antiviral protection. Cell Host Microbe 13:546-57
Eisenlohr, Laurence C (2013) Alternative generation of MHC class II-restricted epitopes: not so exceptional? Mol Immunol 55:169-71
Rubio, Daniel; Xu, Ren-Huan; Remakus, Sanda et al. (2013) Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection. Cell Host Microbe 13:701-10
Remakus, Sanda; Sigal, Luis J (2013) Memory CD8? T cell protection. Adv Exp Med Biol 785:77-86
Ma, Xueying; Xu, Ren-Huan; Roscoe, Felicia et al. (2013) The mature virion of ectromelia virus, a pathogenic poxvirus, is capable of intrahepatic spread and can serve as a target for delayed therapy. J Virol 87:7046-53
Xu, Ren-Huan; Rubio, Daniel; Roscoe, Felicia et al. (2012) Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver. PLoS Pathog 8:e1002475

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