This proposed research seeks to understand how virus and host control innate immune defenses and the outcome of WNV infection. WNV is described as a model flavivirus which is representative of other members of the family. The PL has defined specific PRR pathways and IRFs as key to immune triggering and programming during WNV infection. It is hypothesized that viral triggering and control of PRR and signaling programs and innate immune defenses of the host cell defines the tissue tropism and virulence properties of WNV infection. The PL proposes to conduct in vitro and in vivo studies to 1) define cell specific PRR pathways that trigger innate immunity against WNV 2) Identify the IFN stimulated innate immune effector genes that control WNV replication and 3) determine the molecular mechanism by which pathogenic WNV evades the innate immune actions of IFN?/?.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI083019-02
Application #
7812265
Study Section
Special Emphasis Panel (ZAI1-BDP-I (J3))
Program Officer
Miller, Lara R
Project Start
2009-05-01
Project End
2014-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
2
Fiscal Year
2010
Total Cost
$2,110,046
Indirect Cost
Name
University of Washington
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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