Anti-viral T cell memory is generated following an initial infection, persists longterm in vivo, and can provide protective immunity to viral challenge. The role of virus-specific memory CDS T cells in protective anti-viral responses has been well-characterized;however, considerably less is known about the function of memory CD4 T cells in anti-viral immunity. Memory CD4 T cells can play multifarious roles in coordinating secondary responses via their direct effector functions, and their ability to

Public Health Relevance

Elucidation of the mechanisms by which memory CD4 T cells coordinate secondary anti-viral responses and control viral clearance and immunopathology has strong clinical relevance for improving anti-viral immunity in vaccines, and for designing novel therapies to optimize immune responses to pathogenic viruses such as influenza, where the immune mechanisms leading to viral clearance can also generate pathological reactions, now recognized as the leading cause of death and morbidity from pandemic influenza strains.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI083022-05
Application #
8508814
Study Section
Special Emphasis Panel (ZAI1-BDP-I)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
5
Fiscal Year
2013
Total Cost
$538,384
Indirect Cost
$112,107
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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